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Zhao et al., 2003 - Google Patents

Assembly of the covalent linkage between lipoic acid and its cognate enzymes

Zhao et al., 2003

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Document ID
2162751602940578491
Author
Zhao X
Miller J
Jiang Y
Marletta M
Cronan J
Publication year
Publication venue
Chemistry & biology

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Snippet

Lipoic acid is synthesized from octanoic acid by insertion of sulfur atoms at carbons 6 and 8 and is covalently attached to a pyruvate dehydrogenase (PDH) subunit. We show that sulfur atoms can be inserted into octanoyl moieties attached to a PDH subunit or a derived …
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
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    • C12N9/10—Transferases (2.)
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    • C12N9/10—Transferases (2.)
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    • C12P19/00—Preparation of compounds containing saccharide radicals
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing

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