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Umekage et al., 2009 - Google Patents

In vitro and in vivo production and purification of circular RNA aptamer

Umekage et al., 2009

Document ID
2136366044168945068
Author
Umekage S
Kikuchi Y
Publication year
Publication venue
Journal of biotechnology

External Links

Snippet

RNA aptamers are potential candidates for RNA therapeutics. They must be clinically modified for medical applications because they are vulnerable to indigenous ribonucleases. Since circular RNA molecules without any chemical modification are much more stable than …
Continue reading at www.sciencedirect.com (other versions)

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/12Type of nucleic acid catalytic nucleic acids, e.g. ribozymes
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    • C12N15/09Recombinant DNA-technology
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    • C12N15/1034Isolating an individual clone by screening libraries
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