Yao et al., 2019 - Google Patents
FTY720 inhibits MPP+-induced microglial activation by affecting NLRP3 inflammasome activationYao et al., 2019
View PDF- Document ID
- 2009507641499076289
- Author
- Yao S
- Li L
- Sun X
- Hua J
- Zhang K
- Hao L
- Liu L
- Shi D
- Zhou H
- Publication year
- Publication venue
- Journal of neuroimmune pharmacology
External Links
Snippet
Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons and excessive microglial activation in the substantia nigra pars compacta (SNpc). In the present study, we aimed to demonstrate the therapeutic effectiveness of the potent …
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 CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 0 title abstract description 151
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