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Yao et al., 2019 - Google Patents

FTY720 inhibits MPP+-induced microglial activation by affecting NLRP3 inflammasome activation

Yao et al., 2019

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Document ID
2009507641499076289
Author
Yao S
Li L
Sun X
Hua J
Zhang K
Hao L
Liu L
Shi D
Zhou H
Publication year
Publication venue
Journal of neuroimmune pharmacology

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Snippet

Parkinson's disease (PD) is characterized by the degeneration of dopaminergic neurons and excessive microglial activation in the substantia nigra pars compacta (SNpc). In the present study, we aimed to demonstrate the therapeutic effectiveness of the potent …
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    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/551Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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