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Rosenberger, 1982 - Google Patents

Retinoic acid metabolites. 1. Total synthesis of 4-hydroxy-and 4-oxoretinoic acid

Rosenberger, 1982

Document ID
1860695134023431576
Author
Rosenberger M
Publication year
Publication venue
The Journal of Organic Chemistry

External Links

Snippet

Discussion Several routes to 4-oxygenated retinoic acids have been described1, 12 but none of these methods provedpractical for the preparation of up to 100 g amounts of material which would be needed for extensive biological evaluation. In the past years we …
Continue reading at pubs.acs.org (other versions)

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    • C07C2101/16—The ring being unsaturated
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
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    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
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