[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Sykes, 2007 - Google Patents

Immune tolerance: mechanisms and application in clinical transplantation

Sykes, 2007

View PDF @Full View
Document ID
18317678856037637782
Author
Sykes M
Publication year
Publication venue
Journal of internal medicine

External Links

Snippet

The achievement of immune tolerance, a state of specific unresponsiveness to the donor graft, has the potential to overcome the current major limitations to progress in organ transplantation, namely late graft loss, organ shortage and the toxicities of chronic …
Continue reading at onlinelibrary.wiley.com (PDF) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines

Similar Documents

Publication Publication Date Title
Sykes Immune tolerance: mechanisms and application in clinical transplantation
Zeiser et al. Pathogenesis of acute graft‐versus‐host disease: from intestinal microbiota alterations to donor T cell activation
Ezzelarab et al. Regulatory dendritic cell infusion prolongs kidney allograft survival in nonhuman primates
Gao et al. CD40‐deficient dendritic cells producing interleukin‐10, but not interleukin‐12, induce T‐cell hyporesponsiveness in vitro and prevent acute allograft rejection
CN109069539A (en) Combined immunization therapy use for cancer treatment and cell factor control therapy
Liu et al. Tissue-specific control of tissue-resident memory T cells
Vlad et al. Induction of antigen-specific human T suppressor cells by membrane and soluble ILT3
Asavaroengchai et al. An essential role for IFN-γ in regulation of alloreactive CD8 T cells following allogeneic hematopoietic cell transplantation
US20210147801A1 (en) Methods for increasing expansion and immunosuppressive capacity of a population of cd8+cd45rclow/- tregs
Chong et al. Transplantation tolerance and its outcome during infections and inflammation
Zwar et al. Guarding the immune system: suppression of autoimmunity by CD4+ CD25+ immunoregulatory T cells
Bueno et al. The role of CD8+ T cells during allograft rejection
McCallion et al. Deciphering the contribution of γδ T cells to outcomes in transplantation
Yu et al. Impact of infection on transplantation tolerance
WO2010129770A1 (en) Methods for expanding human t regulatory cells and uses of same
Locatelli et al. Tolerance and hematopoietic stem cell transplantation 50 years after Burnet's theory
Shlomchik et al. The immunobiology of T cell therapies for leukemias
Khalifian et al. Taming inflammation by targeting cytokine signaling: new perspectives in the induction of transplantation tolerance
Issa et al. Immunological principles of acute rejection
Long et al. Regulatory T cells—a journey from rodents to the clinic
Shen et al. Donor-specific regulatory T cells acquired from tolerant mice bearing cardiac allograft promote mixed chimerism and prolong intestinal allograft survival
CA2316089A1 (en) Novel cells and molecules involved in immune regulation
Ellestad Mechanisms underlying lymphopenia-driven autoimmunity in the setting of co-inhibitory molecule deficiency
Priyadharshini Regulation of Early T Cell Activation by TNF Superfamily Members TNF and FASL: A Dissertation
Reed Impacts of Trogocytosis-Mediated Intracellular Signaling on CD4+ T Cell Effector Cytokine Production and Differentiation