Nejatishahidein et al., 2021 - Google Patents
Depth filtration in bioprocessing—new opportunities for an old technologyNejatishahidein et al., 2021
- Document ID
- 18363450461681704690
- Author
- Nejatishahidein N
- Zydney A
- Publication year
- Publication venue
- Current Opinion in Chemical Engineering
External Links
Snippet
Highlights•Renewed interest in depth filtration in bioprocessing.•Depth filters effectively used for both clarification and in-process prefiltration.•Depth filters can also provide HCP, DNA, and virus clearance.•Underlying depth filter structures can be tailored to specific …
- 238000011118 depth filtration 0 title abstract description 39
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
- C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
- C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis, ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/142—Ultrafiltration; Microfiltration comprising multiple ultrafiltration or microfiltration steps
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Zydney | New developments in membranes for bioprocessing–A review | |
Nejatishahidein et al. | Depth filtration in bioprocessing—new opportunities for an old technology | |
Liu et al. | Recovery and purification process development for monoclonal antibody production | |
Yigzaw et al. | Exploitation of the adsorptive properties of depth filters for host cell protein removal during monoclonal antibody purification | |
van Reis et al. | Bioprocess membrane technology | |
Kalyanpur | Downstream processing in the biotechnology industry | |
Bolton et al. | Normal‐flow virus filtration: Detection and assessment of the endpoint in bioprocessing | |
Johnson et al. | Adapting viral safety assurance strategies to continuous processing of biological products | |
CN106103464B (en) | Sterile chromatography and manufacturing process | |
TWI767930B (en) | Methods of processing a fluid including a recombinant therapeutic protein and use thereof | |
CA2882552A1 (en) | Purification of biological molecules | |
Christy et al. | The state-of-the-art of filtration in recovery processes for biopharmaceutical production | |
Nejatishahidein et al. | Effectiveness of host cell protein removal using depth filtration with a filter containing diatomaceous earth | |
CN107567496A (en) | Axenic purification method about virus | |
Gupta et al. | Recent advances in harvest clarification for antibodies and related products | |
Marques et al. | Virus filtration of high‐concentration monoclonal antibody solutions | |
CN114829371A (en) | Enhanced virus filtration using diafiltration buffer | |
Kern et al. | Virus removal by filtration: points to consider | |
Leisi et al. | Visualizing protein fouling and its impact on parvovirus retention within distinct filter membrane morphologies | |
US10329323B2 (en) | Method for purifying antibodies using PBS | |
CA2912765C (en) | A method of determining virus removal from a sample containing a target protein using activated carbon | |
Kandula et al. | Design of a filter train for precipitate removal in monoclonal antibody downstream processing | |
Heldt et al. | Identification of trimeric peptides that bind porcine parvovirus from mixtures containing human blood plasma | |
JP2023145471A (en) | In-line product concentration to reduce volumetric load flow rate and increase productivity of bind and elute chromatography purification | |
Afzal et al. | Impact of proteins and protein fouling on virus retention during virus removal filtration |