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Hu et al., 1993 - Google Patents

Contribution of the B16 and B26 tyrosine residues to the biological activity of insulin

Hu et al., 1993

Document ID
18014506620441768337
Author
Hu S
Burke G
Katsoyannis P
Publication year
Publication venue
Journal of protein chemistry

External Links

Snippet

We report the synthesis and biological evaluation of five insulin analogues in which one or both of the B-chain tyrosine residues have been substituted.[B16 Phe] insulin and [B16 Trp] insulin display a very modest reduction in potency (c. 65%) relative to porcine insulin;[B26 …
Continue reading at link.springer.com (other versions)

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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
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    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
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    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g. HCG; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
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