[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Robles et al., 1994 - Google Patents

Stepwise solid-phase synthesis of the nucleopeptide Phac-Phe-Val-Ser (p3'ACT)-Gly-OH

Robles et al., 1994

Document ID
17850913436394806170
Author
Robles J
Pedroso E
Grandas A
Publication year
Publication venue
The Journal of Organic Chemistry

External Links

Snippet

The nucleopeptide Phac-Phe-Val-Ser (p3'ACT)-Gly-OH, with a phosphodiester bond between the side chain hydroxyl group of a serine residue and the 3'end of a trinucleotide, has beensynthesized by a stepwise procedure. The peptide was first assembled on an …
Continue reading at pubs.acs.org (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/09—Pyrimidine radicals with arabinosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof

Similar Documents

Publication Publication Date Title
Robles et al. Stepwise solid-phase synthesis of the nucleopeptide Phac-Phe-Val-Ser (p3'ACT)-Gly-OH
JP7472018B2 (en) Techniques for preparing oligonucleotides
Van Mansfeld et al. Two juxtaposed tyrosyl-OH groups participate in 0X174 gene A protein catalysed cleavage and ligation of DNA
Schulhof et al. The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups
Fesik et al. Isotope-edited NMR of cyclosporin A bound to cyclophilin: evidence for a trans 9, 10 amide bond
CA2549386C (en) Methods for synthesis of encoded libraries
Bruick et al. Template-directed ligation of peptides to oligonucleotides
Efimov et al. Rapid synthesis of long-chain deoxyribooligonucleotides by the N-methylimidazolide phosphotriester method
JP2008136483A (en) Encoded combinatorial chemical library
Christiansen-Brams et al. Protected-mode synthesis of N-linked glycopeptides: single-step preparation of building blocks as peracetyl glycosylated N α Fmoc asparagine OPfp esters
Köster et al. Polymer support oligonucleotide synthesis-XV: Synthesis of oligodeoxynucleotides on controlled pore glass (CPG) using phosphate and a new phosphite triester approach
Robles et al. Towards nucleopeptides containing any trifunctional amino acid
Peyrottes et al. The synthesis of peptide-oligonucleotide conjugates by a fragment coupling approach
US20030077646A1 (en) Systematic evolution of ligands by exponential enrichment: blended SELEX
Sproat et al. A new linkage for solid phase synthesis of oligodeoxyribonucleotides
Johannsen et al. Amino acids attached to 2′-amino-LNA: synthesis and excellent duplex stability
Zubin et al. Modern methods for the synthesis of peptide–oligonucleotide conjugates
Robles et al. Solid-phase synthesis of a nucleopeptide from the linking site of adenovirus-2 nucleoprotein,-Ser (p 5′ CATCAT)-Gly-Asp-. Convergent versus stepwise strategy
Guibourdenche et al. Use of the Wolff Rearrangement of Diazo Ketones from Amino Acids as a synthetic method for the formation of oligonucleo‐peptides: A novel approach to chimeric biomolecules
Polushin et al. Antisense pro-drugs: 5'-ester oligodeoxynucleotides
US3853845A (en) 5-n-aminoacyl-5-aminouridines
Efimov et al. Dipentafluorophenyl carbonate—a reagent for the synthesis of oligonucleotides and their conjugates
EP0383190B1 (en) Ribonucleotide reductase inhibitors
Flohr et al. Chemoenzymatic synthesis of nucleopeptides
Oakley et al. Synthesis of a hybrid protein containing the iron-binding ligand of bleomycin and the DNA-binding domain of Hin