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Mansour et al., 2006 - Google Patents

Silymarin modulates cisplatin-induced oxidative stress and hepatotoxicity in rats

Mansour et al., 2006

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Document ID
17716046879283125091
Author
Mansour H
Hafez H
Fahmy N
Publication year
Publication venue
BMB Reports

External Links

Snippet

Cisplatin [cis-diamminechloroplatinum (II)](CDDP) is a potent antineoplastic agent used for the treatment of a wide range of cancers (Saad et al., 2004; Wang et al., 2004). Nevertheless, this drug has severe toxic effects that interfere with its therapeutical efficacy …
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl group being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
    • A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
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