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Tayrouz et al., 2003 - Google Patents

Pharmacokinetic and pharmaceutic interaction between digoxin and Cremophor RH40

Tayrouz et al., 2003

Document ID
17310384704904624878
Author
Tayrouz Y
Ding R
Burhenne J
Riedel K
Weiss J
Hoppe‐Tichy T
Haefeli W
Mikus G
Publication year
Publication venue
Clinical Pharmacology & Therapeutics

External Links

Snippet

Background The pharmacokinetics of digoxin is modulated by the efflux pump P‐ glycoprotein. Cremophor EL (BASF Aktiengesellschaft, Ludwigshafen, Germany)(polyoxyl 35 castor oil), a castor oil derivative used to improve the solubilization of drugs and vitamins …
Continue reading at ascpt.onlinelibrary.wiley.com (other versions)

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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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