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Wang et al., 2021 - Google Patents

Discovery of a Potent and Selective FLT3 Inhibitor (Z)-N-(5-((5-Fluoro-2-oxoindolin-3-ylidene) methyl)-4-methyl-1 H-pyrrol-3-yl)-3-(pyrrolidin-1-yl) propanamide with …

Wang et al., 2021

Document ID
17255823255821007225
Author
Wang J
Pan X
Song Y
Liu J
Ma F
Wang P
Liu Y
Zhao L
Kang D
Hu L
Publication year
Publication venue
Journal of Medicinal Chemistry

External Links

Snippet

Overcoming the FLT3-ITD mutant has been a promising drug design strategy for treating acute myeloid leukemia (AML). Herein, we discovered a novel FLT3 inhibitor 17, which displayed potent inhibitory activity against the FLT3-ITD mutant (IC50= 0.8 nM) and …
Continue reading at pubs.acs.org (other versions)

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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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