[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Vinh, 2019 - Google Patents

Proteomics and proteoforms: Bottom-up or top-down, how to use high-resolution mass spectrometry to reach the Grail

Vinh, 2019

View PDF
Document ID
17037037818501366624
Author
Vinh J
Publication year
Publication venue
Fundamentals and Applications of Fourier Transform Mass Spectrometry

External Links

Snippet

Proteomics consists of the dynamic characterization of functional proteins within a biological model in a given environment at a given time. It relies on the use of biological mass spectrometry with upstream purification/fractionation strategies. The study of proteoforms …
Continue reading at hal.science (PDF) (other versions)

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848Methods of protein analysis involving mass spectrometry
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/62Detectors specially adapted therefor
    • G01N30/72Mass spectrometers
    • G01N30/7233Mass spectrometers interfaced to liquid or superfluid chromatograph
    • HELECTRICITY
    • H01BASIC ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometer or separator tubes
    • H01J49/0027Methods for using particle spectrometers
    • H01J49/0036Step by step routines describing the handling of the data generated during a measurement
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
    • G01N27/62Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means by investigating the ionisation of gases; by investigating electric discharges, e.g. emission of cathode
    • HELECTRICITY
    • H01BASIC ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometer or separator tubes
    • H01J49/004Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • HELECTRICITY
    • H01BASIC ELECTRIC ELEMENTS
    • H01JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00Particle spectrometer or separator tubes
    • H01J49/02Details
    • H01J49/04Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components

Similar Documents

Publication Publication Date Title
JP7611343B2 (en) Data-independent acquisition of product ion spectra and reference spectral library matching
JP4818270B2 (en) System and method for grouping precursor and fragment ions using selected ion chromatograms
Cagney et al. De novo peptide sequencing and quantitative profiling of complex protein mixtures using mass-coded abundance tagging
Bowen et al. Dealing with the unknown: metabolomics and metabolite atlases
EP1886135B1 (en) Generation and use of a catalog of polypeptide-related information for chemical analyses
EP1889079B1 (en) Methods for performing retention-time matching
US7781729B2 (en) Analyzing mass spectral data
Schmidt et al. Directed mass spectrometry: towards hypothesis-driven proteomics
Lee et al. A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome
Yuan et al. Mass spectrometric analysis of histone proteoforms
US8455818B2 (en) Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation
Mo et al. Analytical aspects of mass spectrometry and proteomics
Wehr Top-down versus bottom-up approaches in proteomics
Vinh Proteomics and proteoforms: Bottom-up or top-down, how to use high-resolution mass spectrometry to reach the Grail
Leitner et al. SnapShot: mass spectrometry for protein and proteome analyses
Hale et al. Application of proteomics for discovery of protein biomarkers
US20080166696A1 (en) Method for Analyzing Proteins
JP2008039608A (en) Mass spectrometry system
Addona et al. De novo peptide sequencing via manual interpretation of MS/MS spectra
Terence et al. PROTEOMICS IN DRUG TARGET DISCOVERY–
Wu et al. Peptide identification via tandem mass spectrometry
Hjernø et al. Interpretation of Tandem Mass Spectrometry (MS-MS) Spectra for Peptide Analysis
JP2006284509A (en) Mass spectrometric system
Lo et al. A Birds‐Eye View of Modern Proteomics
McKenna et al. The Waters Protein Expression System for Qualitative and Quantitative Proteomics