Vinh, 2019 - Google Patents
Proteomics and proteoforms: Bottom-up or top-down, how to use high-resolution mass spectrometry to reach the GrailVinh, 2019
View PDF- Document ID
- 17037037818501366624
- Author
- Vinh J
- Publication year
- Publication venue
- Fundamentals and Applications of Fourier Transform Mass Spectrometry
External Links
Snippet
Proteomics consists of the dynamic characterization of functional proteins within a biological model in a given environment at a given time. It relies on the use of biological mass spectrometry with upstream purification/fractionation strategies. The study of proteoforms …
- 238000000575 proteomic 0 title abstract description 128
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or superfluid chromatograph
-
- H—ELECTRICITY
- H01—BASIC ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometer or separator tubes
- H01J49/0027—Methods for using particle spectrometers
- H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means by investigating the ionisation of gases; by investigating electric discharges, e.g. emission of cathode
-
- H—ELECTRICITY
- H01—BASIC ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometer or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
-
- H—ELECTRICITY
- H01—BASIC ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometer or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7611343B2 (en) | Data-independent acquisition of product ion spectra and reference spectral library matching | |
JP4818270B2 (en) | System and method for grouping precursor and fragment ions using selected ion chromatograms | |
Cagney et al. | De novo peptide sequencing and quantitative profiling of complex protein mixtures using mass-coded abundance tagging | |
Bowen et al. | Dealing with the unknown: metabolomics and metabolite atlases | |
EP1886135B1 (en) | Generation and use of a catalog of polypeptide-related information for chemical analyses | |
EP1889079B1 (en) | Methods for performing retention-time matching | |
US7781729B2 (en) | Analyzing mass spectral data | |
Schmidt et al. | Directed mass spectrometry: towards hypothesis-driven proteomics | |
Lee et al. | A robust two-dimensional separation for top-down tandem mass spectrometry of the low-mass proteome | |
Yuan et al. | Mass spectrometric analysis of histone proteoforms | |
US8455818B2 (en) | Mass spectrometry data acquisition mode for obtaining more reliable protein quantitation | |
Mo et al. | Analytical aspects of mass spectrometry and proteomics | |
Wehr | Top-down versus bottom-up approaches in proteomics | |
Vinh | Proteomics and proteoforms: Bottom-up or top-down, how to use high-resolution mass spectrometry to reach the Grail | |
Leitner et al. | SnapShot: mass spectrometry for protein and proteome analyses | |
Hale et al. | Application of proteomics for discovery of protein biomarkers | |
US20080166696A1 (en) | Method for Analyzing Proteins | |
JP2008039608A (en) | Mass spectrometry system | |
Addona et al. | De novo peptide sequencing via manual interpretation of MS/MS spectra | |
Terence et al. | PROTEOMICS IN DRUG TARGET DISCOVERY– | |
Wu et al. | Peptide identification via tandem mass spectrometry | |
Hjernø et al. | Interpretation of Tandem Mass Spectrometry (MS-MS) Spectra for Peptide Analysis | |
JP2006284509A (en) | Mass spectrometric system | |
Lo et al. | A Birds‐Eye View of Modern Proteomics | |
McKenna et al. | The Waters Protein Expression System for Qualitative and Quantitative Proteomics |