Hawe et al., 2006 - Google Patents
Impact of freezing procedure and annealing on the physico-chemical properties and the formation of mannitol hydrate in mannitol–sucrose–NaCl formulationsHawe et al., 2006
- Document ID
- 16942762124542268231
- Author
- Hawe A
- Frieß W
- Publication year
- Publication venue
- European journal of pharmaceutics and biopharmaceutics
External Links
Snippet
The goal was to investigate the impact of NaCl on the physico-chemical properties of mannitol–sucrose formulations during freezing and drying, with special focus on mannitol hydrate formation. Differential scanning calorimetry (DSC) and low-temperature X-ray …
- 239000000594 mannitol 0 title abstract description 180
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/06—Organic compounds, e.g. mineral oil, petrolatum, synthetic polyolefins
- A61K47/16—Organic compounds, e.g. mineral oil, petrolatum, synthetic polyolefins containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Quaternary ammonium compounds, e.g. amides, ureas
- A61K47/183—Amino acids or aminosulphonic acids, e.g. glycine, EDTA, aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/06—Organic compounds, e.g. mineral oil, petrolatum, synthetic polyolefins
- A61K47/26—Carbohydrates, e.g. mono-, di-, oligosaccharides, nucleic acids, sugar alcohols, amino sugars; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters, glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/06—Organic compounds, e.g. mineral oil, petrolatum, synthetic polyolefins
- A61K47/08—Organic compounds, e.g. mineral oil, petrolatum, synthetic polyolefins containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Hawe et al. | Impact of freezing procedure and annealing on the physico-chemical properties and the formation of mannitol hydrate in mannitol–sucrose–NaCl formulations | |
| Liao et al. | Influence of processing conditions on the physical state of mannitol—implications in freeze-drying | |
| Liao et al. | Influence of the active pharmaceutical ingredient concentration on the physical state of mannitol—implications in freeze-drying | |
| Kim et al. | The physical state of mannitol after freeze-drying: effects of mannitol concentration, freezing rate, and a noncrystallizing cosolute | |
| Thorat et al. | Characterization of phosphate buffered saline (PBS) in frozen state and after freeze-drying | |
| Horn et al. | Impact of fast and conservative freeze-drying on product quality of protein-mannitol-sucrose-glycerol lyophilizates | |
| Izutsu | Applications of freezing and freeze-drying in pharmaceutical formulations | |
| Piedmonte et al. | Sorbitol crystallization can lead to protein aggregation in frozen protein formulations | |
| Kadoya et al. | Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols | |
| RU2540480C2 (en) | Methods, compositions and sets for lyophilisation | |
| US20070196364A1 (en) | Pharmaceutical Formulation and Process | |
| Sundaramurthi et al. | Calorimetry and complementary techniques to characterize frozen and freeze-dried systems | |
| Jena et al. | Mutual influence of mannitol and trehalose on crystallization behavior in frozen solutions | |
| Horn et al. | Crystallizing amino acids as bulking agents in freeze-drying | |
| US12066246B2 (en) | Target residual moisture content for lyophilized drug product | |
| Thakral et al. | Anomalous behavior of mannitol hemihydrate: Implications on sucrose crystallization in colyophilized systems | |
| Schebor et al. | Glass transition and time-dependent crystallization behavior of dehydration bioprotectant sugars | |
| AU2005225000A1 (en) | Lyophilization method to improve excipient crystallization | |
| Österberg et al. | Physical state of L-histidine after freeze-drying and long-term storage | |
| Dixon et al. | The impact of protein concentration on mannitol and sodium chloride crystallinity and polymorphism upon lyophilization | |
| Sundaramurthi et al. | The effect of crystallizing and non-crystallizing cosolutes on succinate buffer crystallization and the consequent pH shift in frozen solutions | |
| Piedmonte et al. | Sorbitol crystallization-induced aggregation in frozen mAb formulations | |
| Koranne et al. | Effect of formulation and process parameters on the disproportionation of indomethacin sodium in buffered lyophilized formulations | |
| Chatterjee et al. | Partially crystalline systems in lyophilization: I. Use of ternary state diagrams to determine extent of crystallization of bulking agent | |
| Shalaev et al. | Rational choice of excipients for use in lyophilized formulations |