Hosoya et al., 2016 - Google Patents
Cell cycle regulation therapy combined with cytokine blockade enhances antiarthritic effects without increasing immune suppressionHosoya et al., 2016
View PDF- Document ID
- 16873390272354244053
- Author
- Hosoya T
- Iwai H
- Yamaguchi Y
- Kawahata K
- Miyasaka N
- Kohsaka H
- Publication year
- Publication venue
- Annals of the Rheumatic Diseases
External Links
Snippet
Objective Biological disease-modifying antirheumatic drugs (DMARDs) that inhibit aberrant immune reactions in rheumatoid arthritis (RA) cannot induce complete remission in all patients. Combination therapies using two biological DMARDs have failed to exert additive …
- 230000001629 suppression 0 title abstract description 24
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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