Bain et al., 2016 - Google Patents
Chemical synthesis accelerated by paper spray: The haloform reactionBain et al., 2016
View PDF- Document ID
- 16746986896077779918
- Author
- Bain R
- Pulliam C
- Raab S
- Cooks R
- Publication year
- Publication venue
- Journal of Chemical Education
External Links
Snippet
In this laboratory, students perform a synthetic reaction in two ways:(i) by traditional bulk- phase reaction and (ii) in the course of reactive paper spray ionization. Mass spectrometry (MS) is used both as an analytical method and a means of accelerating organic syntheses …
- 239000007921 spray 0 title abstract description 111
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/90—Plate chromatography, e.g. thin layer or paper chromatography
- G01N30/94—Development
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Bain et al. | Chemical synthesis accelerated by paper spray: The haloform reaction | |
Kuo et al. | Ambient ionization mass spectrometry today and tomorrow: embracing challenges and opportunities | |
Tascon et al. | High-throughput screening and quantitation of target compounds in biofluids by coated blade spray-mass spectrometry | |
Law et al. | On the mechanism of extractive electrospray ionization | |
Michely et al. | Paper spray ionization coupled to high resolution tandem mass spectrometry for comprehensive urine drug testing in comparison to liquid chromatography-coupled techniques after urine precipitation or dried urine spot workup | |
Zhang et al. | Membrane electrospray ionization for direct ultrasensitive biomarker quantitation in biofluids using mass spectrometry | |
Hermans et al. | Physicochemical parameters affecting the electrospray ionization efficiency of amino acids after acylation | |
Parajuli et al. | Sensitive determination of triacetone triperoxide explosives using electrogenerated chemiluminescence | |
Dhummakupt et al. | Direct analysis of aerosolized chemical warfare simulants captured on a modified glass-based substrate by “paper-spray” ionization | |
Kulyk et al. | Reactive charged droplets for reduction of matrix effects in electrospray ionization mass spectrometry | |
Lohmann et al. | Covalent protein modification by reactive drug metabolites using online electrochemistry/liquid chromatography/mass spectrometry | |
Nanita et al. | High-throughput pesticide residue quantitative analysis achieved by tandem mass spectrometry with automated flow injection | |
Sarkar et al. | Catalytic paper spray ionization mass spectrometry with metal nanotubes and the detection of 2, 4, 6-trinitrotoluene | |
Kim et al. | Paper spray chemical ionization: highly sensitive ambient ionization method for low-and nonpolar aromatic compounds | |
Jordan et al. | Tips on making tiny tips: Secrets to submicron nanoelectrospray emitters | |
Zhu et al. | The expanding role of electrospray ionization mass spectrometry for probing reactive intermediates in solution | |
Famiglini et al. | Single-step LC/MS method for the simultaneous determination of GC-amenable organochlorine and LC-amenable phenoxy acidic pesticides | |
Wang et al. | A “soft” and “hard” ionization method for comprehensive studies of molecules | |
Ma et al. | Versatile platform employing desorption electrospray ionization mass spectrometry for high-throughput analysis | |
Cheng et al. | Online monitoring of enzymatic reactions using time-resolved desorption electrospray ionization mass spectrometry | |
Zhao et al. | In situ ion-transmission mass spectrometry for paper-based analytical devices | |
Beach et al. | Nontarget analysis of urine by electrospray ionization-high field asymmetric waveform ion mobility-tandem mass spectrometry | |
Munisamy et al. | Direct infusion electrospray ionization–ion mobility–high resolution mass spectrometry (DIESI-IM-HRMS) for rapid characterization of potential bioprocess streams | |
Duan et al. | Gas-phase reactions of ClMn (H2O)+ with polar and nonpolar hydrocarbons in a mass spectrometer | |
Liu et al. | based electrochemical cell coupled to mass spectrometry |