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Luo et al., 2024 - Google Patents

MCL attenuates atherosclerosis by suppressing macrophage ferroptosis via targeting KEAP1/NRF2 interaction

Luo et al., 2024

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Document ID
16233197986462255306
Author
Luo X
Wang Y
Zhu X
Chen Y
Xu B
Bai X
Weng X
Xu J
Tao Y
Yang D
Du J
Lv Y
Zhang S
Hu S
Li J
Jia H
Publication year
Publication venue
Redox biology

External Links

Snippet

Background Micheliolide (MCL), which is the active metabolite of parthenolide, has demonstrated promising clinical application potential. However, the effects and underlying mechanisms of MCL on atherosclerosis are still unclear. Method ApoE−/− mice were fed …
Continue reading at www.sciencedirect.com (HTML) (other versions)

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    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. cannabinols, methantheline
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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