Kukis et al., 1994 - Google Patents
A comparative study of copper‐67 radiolabeling and kinetic stabilities of antibody‐macrocycle chelate conjugatesKukis et al., 1994
View PDF- Document ID
- 16032771028205129212
- Author
- Kukis D
- Diril H
- Greiner D
- Denardo S
- Denardo G
- Salako Q
- Meares C
- Publication year
- Publication venue
- Cancer
External Links
Snippet
Background. The development of new chelating agents and radiolabeling protocols is essential to progress in radioimmunotherapy with antibody‐chelate conjugates. Methods. Immunoconjugates of four polyazamacrocycles with N‐bonded acetate groups were …
- 238000000163 radioactive labelling 0 title abstract description 21
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
- A61K51/1003—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody not used, see subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
- A61K51/0474—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/48—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
- A61K47/48369—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the modifying part being an antibody, an immunoglobulin, or a fragment thereof, e.g. a Fc-fragment
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kukis et al. | A comparative study of copper‐67 radiolabeling and kinetic stabilities of antibody‐macrocycle chelate conjugates | |
| Meares et al. | Macrocyclic chelates of radiometals for diagnosis and therapy. | |
| Li et al. | Synthesis, metal chelate stability studies, and enzyme digestion of a peptide-linked DOTA derivative and its corresponding radiolabeled immunoconjugates | |
| US5286850A (en) | Antibody DTPA-type ligand conjugates | |
| US4988496A (en) | Metal radionuclide chelating compounds for improved chelation kinetics | |
| US5635157A (en) | Synthesis of 4-substituted-trans-1,2-diaminocyclohexyl polyaminocarboxylate metal chelating agents for the preparation of stable radiometal antibody immunoconjugates for therapy and spect and pet imaging | |
| Kasina et al. | Development and biologic evaluation of a kit for preformed chelate technetium-99m radiolabeling of an antibody Fab fragment using a diamide dimercaptide chelating agent | |
| KR920003590B1 (en) | Backbone polysubstituted chelates for forming metal chelate-protein conjugate | |
| US5436352A (en) | Metal radionuclide chelating compounds for improved chelation kinetics | |
| Brechbiel et al. | Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies | |
| Wu et al. | Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA | |
| US5756065A (en) | Macrocyclic tetraazacyclododecane conjugates and their use as diagnostic and therapeutic agents | |
| EP0455268B1 (en) | Biologically useful conjugates | |
| Meares | Chelating agents for the binding of metal ions to antibodies | |
| US5292868A (en) | Chelating agents for attaching metal ions to proteins | |
| US5180816A (en) | One vial method for labeling protein/linker conjugates with technetium-99M | |
| IE892045L (en) | Macrocyclic bifunctional chelants, complexes thereof and¹their antibody conjugates | |
| CA2131382A1 (en) | Conjugates of biotin and deferoxamine for radioimmunoimaging and radioimmunotherapy | |
| US6517814B2 (en) | Macrocyclic chelants useful for metallopharmaceuticals | |
| JPH01113349A (en) | Polydental chelating agent composed of 8-hydroxyquinoline unit | |
| EP0484989B1 (en) | Polysubstituted diethylenetriamine chelates for forming a metal-chelate-protein conjugate | |
| Renn et al. | New approaches to delivering metal-labeled antibodies to tumors: Synthesis and characterization of new biotinyl chelate conjugates for pre-targeted diagnosis and therapy | |
| KR100199892B1 (en) | Chelating agents for attaching metal ions to proteins | |
| Subramanian et al. | Bifunctional chelating agents for radiometal-labeled monoclonal antibodies | |
| JPH11513374A (en) | (Radioactive) labeled biotin derivatives |