Zhang et al., 2023 - Google Patents
Complete remission of tumors in mice with neoantigen-painted exosomes and anti-PD-1 therapyZhang et al., 2023
- Document ID
- 1544254052580076991
- Author
- Zhang Y
- Zuo B
- Yu Z
- Zhao K
- Zhang Y
- He K
- Seow Y
- Yin H
- Publication year
- Publication venue
- Molecular Therapy
External Links
Snippet
Neoantigen-based cancer vaccines are emerging as promising tumor therapies, but enhancement of immunogenicity can further improve therapeutic outcomes. Here, we demonstrate that anchoring different peptide neoantigens on subcutaneously administered …
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Zuo et al. | Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice | |
| Sun et al. | Intelligent photothermal dendritic cells restart the cancer immunity cycle through enhanced immunogenic cell death | |
| Ruan et al. | Extracellular vesicles as an advanced delivery biomaterial for precision cancer immunotherapy | |
| Zhang et al. | Exosomes as smart drug delivery vehicles for cancer immunotherapy | |
| Ma et al. | Copresentation of tumor antigens and costimulatory molecules via biomimetic nanoparticles for effective cancer immunotherapy | |
| US20120034155A1 (en) | Artificial cells | |
| JP7282874B2 (en) | Exosome-based anti-tumor vaccine | |
| Qian et al. | The roles of small extracellular vesicles in cancer and immune regulation and translational potential in cancer therapy | |
| Zhang et al. | Complete remission of tumors in mice with neoantigen-painted exosomes and anti-PD-1 therapy | |
| CN101511384A (en) | Dendritic cells generated using GM-CSF and interferon alpha and loaded with heat-treated and killed cancer cells | |
| Lee et al. | Dendritic cell vaccines: A shift from conventional approach to new generations | |
| Chen et al. | Functional nanovesicles displaying anti-PD-L1 antibodies for programmed photoimmunotherapy | |
| Li et al. | Tumor Cell Nanovaccines Based on Genetically Engineered Antibody‐Anchored Membrane | |
| Park et al. | Personalized combination nano-immunotherapy for robust induction and tumor infiltration of CD8+ T cells | |
| Thomas et al. | Exosomes: biological pharmaceutical nanovectors for theranostics | |
| Zhang et al. | Lipid–Polymer Hybrid Nanoparticles Utilize B Cells and Dendritic Cells to Elicit Distinct Antigen-Specific CD4+ and CD8+ T Cell Responses | |
| Liu et al. | Exploiting immunostimulatory mechanisms of immunogenic cell death to develop membrane-encapsulated nanoparticles as a potent tumor vaccine | |
| Kang et al. | Self-assembled nanoparticles based on DNA origami and a nitrated T helper cell epitope as a platform for the development of personalized cancer vaccines | |
| Yan et al. | Nano-adjuvants and immune agonists promote antitumor immunity of peptide amphiphiles | |
| Lei et al. | Engineered Bacteriophage-Based In Situ Vaccine Remodels a Tumor Microenvironment and Elicits Potent Antitumor Immunity | |
| Berti et al. | Reduction-sensitive protein nanogels enhance uptake of model and tumor lysate antigens in vitro by mouse-and human-derived dendritic cells | |
| Shi et al. | HMGB1/GPC3 dual targeting vaccine induces dendritic cells-mediated CD8+ T cell immune response and elicits potential therapeutic effect in hepatocellular carcinoma | |
| Diao et al. | Across-cancer specific immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis | |
| Zhang et al. | Integration of Protein Nanocage with CpG Motifs: A Virus‐Mimicked Core‐Shell Nanostructure to Ignite Antitumor Immunity | |
| Zheng et al. | Engineered Bacterial Biomimetic Vesicles Reprogram Tumor-Associated Macrophages and Remodel Tumor Microenvironment to Promote Innate and Adaptive Antitumor Immune Responses |