Nugrahani et al., 2020 - Google Patents
Composing novel diclofenac potassium and l-proline salt cocrystal as a strategy to increase solubility and dissolutionNugrahani et al., 2020
- Document ID
- 15333295119045906968
- Author
- Nugrahani I
- Komara S
- Horikawa A
- Uekusa H
- Publication year
- Publication venue
- Journal of Pharmaceutical Sciences
External Links
Snippet
This research dealt with the multicomponent crystal developed from diclofenac potassium and l-proline to improve the pharmaceutical performance of this anti-inflammatory drug. Slow evaporation of the component mixture at a 1: 1 M ratio, supported by ultrasonication …
- KXZOIWWTXOCYKR-UHFFFAOYSA-M diclofenac potassium data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300.0' height='300.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-1 atom-2' d='M 35.1,225.5 L 39.8,213.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-1 atom-2' d='M 39.8,213.2 L 44.4,200.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-2 atom-3' d='M 47.6,198.3 L 40.2,189.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-2 atom-3' d='M 40.2,189.3 L 32.8,180.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-2 atom-3' d='M 41.2,203.5 L 33.9,194.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-2 atom-3' d='M 33.9,194.4 L 26.5,185.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-4' d='M 44.4,200.9 L 84.7,194.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-4 atom-5' d='M 84.7,194.3 L 99.2,156.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-5 atom-6' d='M 99.2,156.1 L 73.3,124.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-5 atom-6' d='M 101.6,146.1 L 83.5,124.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-10 atom-5' d='M 139.5,149.5 L 99.2,156.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-6 atom-7' d='M 73.3,124.4 L 87.8,86.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-7 atom-8' d='M 87.8,86.2 L 128.1,79.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-7 atom-8' d='M 95.1,93.3 L 123.4,88.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-8 atom-9' d='M 128.1,79.6 L 154.0,111.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-9 atom-10' d='M 154.0,111.2 L 139.5,149.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-9 atom-10' d='M 144.2,114.1 L 134.0,140.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-10 atom-11' d='M 139.5,149.5 L 147.4,159.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-10 atom-11' d='M 147.4,159.2 L 155.4,168.8' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-11 atom-12' d='M 179.4,178.8 L 192.5,176.7' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-11 atom-12' d='M 192.5,176.7 L 205.7,174.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-12 atom-13' d='M 205.7,174.5 L 231.6,206.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-12 atom-13' d='M 215.9,174.1 L 234.0,196.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-18 atom-12' d='M 220.2,136.3 L 205.7,174.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-13 atom-14' d='M 231.6,206.1 L 226.9,218.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-13 atom-14' d='M 226.9,218.5 L 222.3,230.8' style='fill:none;fill-rule:evenodd;stroke:#5BB772;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-15' d='M 231.6,206.1 L 271.9,199.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-15 atom-16' d='M 271.9,199.5 L 286.4,161.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-15 atom-16' d='M 266.4,190.9 L 276.6,164.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-16 atom-17' d='M 286.4,161.3 L 260.5,129.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-17 atom-18' d='M 260.5,129.7 L 220.2,136.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-17 atom-18' d='M 255.8,138.7 L 227.5,143.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-18 atom-19' d='M 220.2,136.3 L 211.1,125.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-18 atom-19' d='M 211.1,125.2 L 202.0,114.1' style='fill:none;fill-rule:evenodd;stroke:#5BB772;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='148.4' y='60.6' class='atom-0' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#3B4143' >K</text>
<text x='159.7' y='54.0' class='atom-0' style='font-size:10px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#3B4143' >+</text>
<text x='25.1' y='247.3' class='atom-1' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='36.3' y='240.7' class='atom-1' style='font-size:10px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='13.6' y='177.4' class='atom-3' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='149.2' y='189.3' class='atom-11' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
<text x='160.5' y='189.3' class='atom-11' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='204.3' y='252.5' class='atom-14' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >C</text>
<text x='215.6' y='252.5' class='atom-14' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >l</text>
<text x='181.5' y='112.8' class='atom-19' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >C</text>
<text x='192.8' y='112.8' class='atom-19' style='font-size:16px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >l</text>
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85.0' height='85.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-1 atom-2' d='M 9.0,65.0 L 10.7,60.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-1 atom-2' d='M 10.7,60.6 L 12.3,56.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-2 atom-3' d='M 13.2,55.6 L 10.6,52.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-2 atom-3' d='M 10.6,52.4 L 8.0,49.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-2 atom-3' d='M 11.4,57.0 L 8.8,53.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-2 atom-3' d='M 8.8,53.8 L 6.2,50.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-4' d='M 12.3,56.3 L 23.7,54.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-4 atom-5' d='M 23.7,54.4 L 27.8,43.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-5 atom-6' d='M 27.8,43.6 L 20.5,34.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-5 atom-6' d='M 28.5,40.8 L 23.4,34.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-18 atom-10 atom-5' d='M 39.2,41.8 L 27.8,43.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-6 atom-7' d='M 20.5,34.7 L 24.6,23.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-7 atom-8' d='M 24.6,23.9 L 35.9,22.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-7 atom-8' d='M 26.6,25.9 L 34.6,24.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-8 atom-9' d='M 35.9,22.0 L 43.2,31.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-9 atom-10' d='M 43.2,31.0 L 39.2,41.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-9 atom-10' d='M 40.5,31.8 L 37.6,39.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-10 atom-11' d='M 39.2,41.8 L 42.0,45.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-10 atom-11' d='M 42.0,45.2 L 44.8,48.6' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-11 atom-12' d='M 48.6,50.4 L 53.2,49.6' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-11 atom-12' d='M 53.2,49.6 L 57.9,48.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-12 atom-13' d='M 57.9,48.8 L 65.2,57.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-12 atom-13' d='M 60.7,48.7 L 65.9,55.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-19 atom-18 atom-12' d='M 61.9,38.0 L 57.9,48.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-13 atom-14' d='M 65.2,57.8 L 63.5,62.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-13 atom-14' d='M 63.5,62.1 L 61.9,66.5' style='fill:none;fill-rule:evenodd;stroke:#5BB772;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-15' d='M 65.2,57.8 L 76.6,55.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-15 atom-16' d='M 76.6,55.9 L 80.6,45.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-14 atom-15 atom-16' d='M 75.0,53.5 L 77.9,45.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-15 atom-16 atom-17' d='M 80.6,45.1 L 73.3,36.2' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-17 atom-18' d='M 73.3,36.2 L 61.9,38.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-16 atom-17 atom-18' d='M 72.0,38.7 L 64.0,40.0' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-18 atom-19' d='M 61.9,38.0 L 58.7,34.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-17 atom-18 atom-19' d='M 58.7,34.1 L 55.5,30.1' style='fill:none;fill-rule:evenodd;stroke:#5BB772;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='41.3' y='17.3' class='atom-0' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#3B4143' >K</text>
<text x='45.4' y='14.9' class='atom-0' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#3B4143' >+</text>
<text x='6.4' y='70.1' class='atom-1' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='10.6' y='67.7' class='atom-1' style='font-size:3px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >-</text>
<text x='3.2' y='50.4' class='atom-3' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='40.5' y='53.7' class='atom-11' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
<text x='44.7' y='53.7' class='atom-11' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='56.4' y='71.6' class='atom-14' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >C</text>
<text x='60.5' y='71.6' class='atom-14' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >l</text>
<text x='49.9' y='32.1' class='atom-19' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >C</text>
<text x='54.1' y='32.1' class='atom-19' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >l</text>
</svg>
 [K+].[O-]C(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl 0 title abstract description 51
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Nugrahani et al. | Composing novel diclofenac potassium and l-proline salt cocrystal as a strategy to increase solubility and dissolution | |
| Park et al. | Emodin-nicotinamide (1: 2) cocrystal identified by thermal screening to improve emodin solubility | |
| Fucke et al. | How good are the crystallisation methods for co-crystals? A comparative study of piroxicam | |
| Deng et al. | Dapagliflozin-citric acid cocrystal showing better solid state properties than dapagliflozin | |
| ES2309090T3 (en) | SALTS OF VALSARTAN. | |
| Zhang et al. | Thermodynamics and crystallization of a theophylline–salicylic acid cocrystal | |
| Chun et al. | Characteristics of indomethacin–saccharin (IMC–SAC) co-crystals prepared by an anti-solvent crystallization process | |
| Caira et al. | Co-crystals of the antiretroviral nevirapine: crystal structures, thermal analysis and dissolution behaviour | |
| Wang et al. | 2: 1 5-Fluorocytosine–acesulfame CAB cocrystal and 1: 1 5-fluorocytosine–acesulfame salt hydrate with enhanced stability against hydration | |
| Khatioda et al. | Solubility and in vitro drug permeation behavior of ethenzamide cocrystals regulated in physiological pH environments | |
| Chen et al. | Development of a pharmaceutical cocrystal of a monophosphate salt with phosphoric acid | |
| Abourahma et al. | Examining the robustness of a theophylline cocrystal during grinding with additives | |
| Perumalla et al. | Robust bulk preparation and characterization of sulfamethazine and saccharine salt and cocrystal polymorphs | |
| Grepioni et al. | Ionic co-crystals of racetams: solid-state properties enhancement of neutral active pharmaceutical ingredients via addition of Mg 2+ and Ca 2+ chlorides | |
| Khanfar et al. | Preparation and evaluation of co-amorphous formulations of telmisartan—amino acids as a potential method for solubility and dissolution enhancement | |
| Lemmerer et al. | Synthesis characterization molecular modeling of a pharmaceutical co-crystal:(2-chloro-4-nitrobenzoic acid):(nicotinamide) | |
| Li et al. | Discovered two polymorphs and two solvates of lamotrigine-tolfenamic acid salt: Thermal behavior and crystal morphological differences | |
| Li et al. | Multicomponent crystals of clotrimazole: A combined theoretical and experimental study | |
| Xia et al. | Rucaparib cocrystal: Improved solubility and bioavailability over camsylate | |
| Friščić et al. | A rational approach to screen for hydrated forms of the pharmaceutical derivative magnesium naproxen using liquid-assisted grinding | |
| Li et al. | Eutectics and salt of dapsone with hydroxybenzoic acids: binary phase diagrams, characterization and evaluation | |
| Chen et al. | A novel soluble lornoxicam-sodium chelate monohydrate with improved plasticity and tabletability | |
| WO2015007206A1 (en) | Afatinib acid addition salts and crystal forms thereof, preparation method and pharmaceutical composition thereof | |
| Samipillai et al. | Co-amorphous solids of dasatinib and olanzapine by saccharin with promising physicochemical properties | |
| Nugrahani et al. | Theophylline-Na-sacharrine single crystal isolation for its structure determination |