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Nasimuzzaman et al., 2005 - Google Patents

Eradication of Epstein–Barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative …

Nasimuzzaman et al., 2005

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Document ID
14866041035355108506
Author
Nasimuzzaman M
Kuroda M
Dohno S
Yamamoto T
Iwatsuki K
Matsuzaki S
Mohammad R
Kumita W
Mizuguchi H
Hayakawa T
Nakamura H
Taguchi T
Wakiguchi H
Imai S
Publication year
Publication venue
Molecular Therapy

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Epstein–Barr virus (EBV) nuclear antigen 1 (EBNA1), a latent viral protein consistently expressed in infected proliferating cells, is essentially required in trans to maintain EBV episomes in cells. We constructed a mutant (mt) EBNA1 and examined whether it exerted …
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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