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Shimizu et al., 1990 - Google Patents

Microbial asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to optically active ethyl-4-chloro-3-hydroxybutanoate

Shimizu et al., 1990

Document ID
14844696343048477158
Author
Shimizu S
Kataoka M
Morishita A
Katoh M
Morikawa T
Miyoshi T
Yamada H
Publication year
Publication venue
Biotechnology letters

External Links

Snippet

The synthesis of ethyl (R)-4-chloro-3-hydroxybutanoate through the asymmetric reduction of ethyl 4-chloro-3-oxobutanoate with the NADPH-dependent aldehyde reductase of Sporobolomyces salmonicolor AKU 4429 is described. Under preparative scale reaction …
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
    • C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
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