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Serrano et al., 2019 - Google Patents

Complementary activity of tyrosine kinase inhibitors against secondary kit mutations in imatinib-resistant gastrointestinal stromal tumours

Serrano et al., 2019

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Document ID
14513534424504678580
Author
Serrano C
Mariño-Enríquez A
Tao D
Ketzer J
Eilers G
Zhu M
Yu C
Mannan A
Rubin B
Demetri G
Raut C
Presnell A
McKinley A
Heinrich M
Czaplinski J
Sicinska E
Bauer S
George S
Fletcher J
Publication year
Publication venue
British journal of cancer

External Links

Snippet

Background Most patients with KIT-mutant gastrointestinal stromal tumours (GISTs) benefit from imatinib, but treatment resistance results from outgrowth of heterogeneous subclones with KIT secondary mutations. Once resistance emerges, targeting KIT with tyrosine kinase …
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