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Kremer et al., 2012 - Google Patents

A phase IIb dose‐ranging study of the oral JAK inhibitor tofacitinib (CP‐690,550) versus placebo in combination with background methotrexate in patients with active …

Kremer et al., 2012

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Document ID
14447362792263786151
Author
Kremer J
Cohen S
Wilkinson B
Connell C
French J
Gomez‐Reino J
Gruben D
Kanik K
Krishnaswami S
Pascual‐Ramos V
Wallenstein G
Zwillich S
Publication year
Publication venue
Arthritis & Rheumatism

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Objective To compare the efficacy, safety, and tolerability of 6 dosages of oral tofacitinib (CP‐ 690,550) with placebo for the treatment of active rheumatoid arthritis (RA) in patients receiving a stable background regimen of methotrexate (MTX) who have an inadequate …
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    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/513Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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Kremer et al. A phase IIb dose‐ranging study of the oral JAK inhibitor tofacitinib (CP‐690,550) versus placebo in combination with background methotrexate in patients with active rheumatoid arthritis and an inadequate response to methotrexate alone
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