[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Xu et al., 2020 - Google Patents

Systemic in silico screening in drug discovery for coronavirus disease (COVID-19) with an online interactive web server

Xu et al., 2020

View PDF
Document ID
14328859081129459254
Author
Xu C
Ke Z
Liu C
Wang Z
Liu D
Zhang L
Wang J
He W
Xu Z
Li Y
Yang Y
Huang Z
Lv P
Wang X
Han D
Li Y
Qiao N
Liu B
Publication year
Publication venue
Journal of Chemical information and modeling

External Links

Snippet

The emergence of the new coronavirus (nCoV-19) has impacted human health on a global scale, while the interaction between the virus and the host is the foundation of the disease. The viral genome codes a cluster of proteins, each with a unique function in the event of host …
Continue reading at pubs.acs.org (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING; COUNTING
    • G06F—ELECTRICAL DIGITAL DATA PROCESSING
    • G06F19/00—Digital computing or data processing equipment or methods, specially adapted for specific applications
    • G06F19/10—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
    • G06F19/22—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for sequence comparison involving nucleotides or amino acids, e.g. homology search, motif or SNP [Single-Nucleotide Polymorphism] discovery or sequence alignment
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING; COUNTING
    • G06F—ELECTRICAL DIGITAL DATA PROCESSING
    • G06F19/00—Digital computing or data processing equipment or methods, specially adapted for specific applications
    • G06F19/10—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
    • G06F19/18—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions

Similar Documents

Publication Publication Date Title
Xu et al. Systemic in silico screening in drug discovery for coronavirus disease (COVID-19) with an online interactive web server
Romano et al. A structural view of SARS-CoV-2 RNA replication machinery: RNA synthesis, proofreading and final capping
Gil et al. COVID-19: drug targets and potential treatments
Su et al. Molecular Insights into Small‐Molecule Drug Discovery for SARS‐CoV‐2
Guedes et al. Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants
Mariano et al. Structural characterization of SARS-CoV-2: where we are, and where we need to be
Cannalire et al. Targeting SARS-CoV-2 proteases and polymerase for COVID-19 treatment: state of the art and future opportunities
Gorkhali et al. Structure and function of major SARS-CoV-2 and SARS-CoV proteins
Yang et al. Structural biology of SARS-CoV-2 and implications for therapeutic development
Hatmal et al. Comprehensive structural and molecular comparison of spike proteins of SARS-CoV-2, SARS-CoV and MERS-CoV, and their interactions with ACE2
Kadam et al. SARS‐CoV‐2, the pandemic coronavirus: Molecular and structural insights
Ogando et al. The curious case of the nidovirus exoribonuclease: its role in RNA synthesis and replication fidelity
Freitas et al. Characterization and noncovalent inhibition of the deubiquitinase and deISGylase activity of SARS-CoV-2 papain-like protease
Chien et al. Nucleotide analogues as inhibitors of SARS-CoV-2 polymerase, a key drug target for COVID-19
Picarazzi et al. Targeting the RdRp of emerging RNA viruses: the structure-based drug design challenge
Ng et al. Antiviral drug discovery for the treatment of COVID-19 infections
Asghari et al. The novel insight of SARS-CoV-2 molecular biology and pathogenesis and therapeutic options
Lubin et al. Evolution of the SARS‐CoV‐2 proteome in three dimensions (3D) during the first 6 months of the COVID‐19 pandemic
Chen et al. Synergistic inhibition of SARS-CoV-2 replication using disulfiram/ebselen and remdesivir
Corona et al. Natural compounds inhibit SARS-CoV-2 nsp13 unwinding and ATPase enzyme activities
Low et al. SARS-CoV-2 non-structural proteins and their roles in host immune evasion
Cavasotto et al. Functional and druggability analysis of the SARS-CoV-2 proteome
Qiu et al. Functional studies of the coronavirus nonstructural proteins
Chen et al. SARS-CoV-2 Mpro protease variants of concern display altered viral substrate and cell host target Galectin-8 processing but retain sensitivity toward antivirals
Stevaert et al. Betulonic acid derivatives interfering with human coronavirus 229E replication via the nsp15 endoribonuclease