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Yeu et al., 2023 - Google Patents

Treatment of Demodex blepharitis: a prospective, randomized, controlled, double-masked clinical trial comparing topical lotilaner ophthalmic solution, 0.25% eyedrops …

Yeu et al., 2023

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Document ID
14305629441381132417
Author
Yeu E
Holdbrook M
Baba S
Ceballos J
Massaro-Corredor M
Corredor-Ortega C
Ramos-Betancourt N
Quiroz-Mercado H
Gonzalez-Salinas R
Publication year
Publication venue
Ocular Immunology and Inflammation

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Purpose To evaluate the efficacy and safety of lotilaner ophthalmic solution, 0.25% eyedrops compared to vehicle for the treatment of Demodex blepharitis. Methods In this randomized, controlled, double-masked clinical trial, 54 participants were randomly assigned in a 1: 1 …
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    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
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    • A61K47/06—Organic compounds, e.g. mineral oil, petrolatum, synthetic polyolefins

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