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Sakaue et al., 2024 - Google Patents

Tissue-specific enhancer–gene maps from multimodal single-cell data identify causal disease alleles

Sakaue et al., 2024

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Document ID
14142076132166109055
Author
Sakaue S
Weinand K
Isaac S
Dey K
Jagadeesh K
Kanai M
Watts G
Zhu Z
Accelerating Medicines Partnership® RA/SLE Program and Network Albrecht Jennifer 14 Anolik Jennifer H. 14 Apruzzese William 15 Banda Nirmal 16 Barnas Jennifer L. 14 Bathon Joan M. 17 Ben-Artzi Ami 18 Boyce Brendan F. 19 Boyle David L. 20 Bridges S. Louis Jr 11 12 Bykerk Vivian P. 11 12 Campbell Debbie 14 Carr Hayley L. 21 Ceponis Arnold 20 Chicoine Adam 9 Cordle Andrew 22 Curtis Michelle 1 2 3 Deane Kevin D. 23 DiCarlo Edward 24 Dunn Patrick 25 26 Filer Andrew 21 Firestein Gary S. 20 Forbess Lindsy 21 Geraldino-Pardilla Laura 17 Goodman Susan M. 11 12 Gravallese Ellen M. 9 Gregersen Peter K. 27 Guthridge Joel M. 28 Gutierrez-Arcelus Maria 1 2 3 29 Gurajala Siddarth 1 2 3 Michael Holers V. 23 Horowitz Diane 27 Hughes Laura B. 30 Ishigaki Kazuyoshi 1 2 3 31 Ivashkiv Lionel B. 11 12 James Judith A. 28 Jonsson Anna Helena 9 Kang Joyce B. 1 2 3 4 Keras Gregory 9 Korsunsky Ilya 1 2 3 Lakhanpal Amit 11 12 Lederer James A. 32 Li Zhihan J. 9 Li Yuhong 9 Liao Katherine P. 4 9 Mandelin Arthur M. II 33 Mantel Ian 11 12 Maybury Mark 21 Mears Joseph 1 2 3 Meednu Nida 14 Millard Nghia 1 2 3 4 Moreland Larry W. 23 34 Nathan Aparna 1 2 3 4 Nerviani Alessandra 35 Orange Dana E. 11 36 Perlman Harris 33 Pitzalis Costantino 35 Rangel-Moreno Javier 14 Rao Deepak A. 9 Raza Karim 21 Reshef Yakir 1 2 3 Ritchlin Christopher 14 Rivellese Felice 35 Robinson William H. 37 Rumker Laurie 1 2 3 4 Sahbudin Ilfita 21 Seifert Jennifer A. 23 Slowikowski Kamil 4 38 39 Smith Melanie H. 11 Tabechian Darren 14 Scheel-Toellner Dagmar 21 Utz Paul J. 37 Weisenfeld Dana 9 Weisman Michael H. 18 37 Xiao Qian 1 2 3 Zhang Fan 1 2 3 40
Brenner M
McDavid A
Donlin L
Wei K
Price A
Raychaudhuri S
Publication year
Publication venue
Nature genetics

External Links

Snippet

Translating genome-wide association study (GWAS) loci into causal variants and genes requires accurate cell-type-specific enhancer–gene maps from disease-relevant tissues. Building enhancer–gene maps is essential but challenging with current experimental …
Continue reading at www.medrxiv.org (PDF) (other versions)

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    • G06F19/18—Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
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