[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Liu et al., 2021 - Google Patents

Precipitated fluorophore-based molecular probe for in situ imaging of aminopeptidase N in living cells and tumors

Liu et al., 2021

Document ID
13943113931849045565
Author
Liu Y
Xu C
Liu H
Teng L
Huan S
Yuan L
Zhang X
Publication year
Publication venue
Analytical Chemistry

External Links

Snippet

Aminopeptidase N (APN) is capable of cleaving N-terminal amino acids from peptides with alanine in the N-terminal position and plays a key role in the growth, migration, and metastasis of cancer. However, reliable in situ information is hard to be obtained with the …
Continue reading at pubs.acs.org (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay
    • G01N33/543—Immunoassay; Biospecific binding assay with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay
    • G01N33/574—Immunoassay; Biospecific binding assay for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay
    • G01N33/573—Immunoassay; Biospecific binding assay for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving hydrolase

Similar Documents

Publication Publication Date Title
Liu et al. Precipitated fluorophore-based molecular probe for in situ imaging of aminopeptidase N in living cells and tumors
Li et al. Facile and sensitive near-infrared fluorescence probe for the detection of endogenous alkaline phosphatase activity in vivo
Ou-Yang et al. Fluorescence-guided cancer diagnosis and surgery by a zero cross-talk ratiometric near-infrared γ-glutamyltranspeptidase fluorescent probe
Li et al. In vivo visualization of γ-Glutamyl transpeptidase activity with an activatable self-immobilizing near-infrared probe
Zhou et al. A ratiometric fluorescent probe for monitoring leucine aminopeptidase in living cells and zebrafish model
Huang et al. A new strategy: distinguishable multi-substance detection, multiple pathway tracing based on a new site constructed by the reaction process and its tumor targeting
Li et al. An activatable AIEgen probe for high‐fidelity monitoring of overexpressed tumor enzyme activity and its application to surgical tumor excision
Li et al. Imaging γ-Glutamyltranspeptidase for tumor identification and resection guidance via enzyme-triggered fluorescent probe
Niu et al. Near-infrared probe based on rhodamine derivative for highly sensitive and selective lysosomal pH tracking
Kawatani et al. Fluorescence detection of prostate cancer by an activatable fluorescence probe for PSMA carboxypeptidase activity
Hananya et al. Remarkable enhancement of chemiluminescent signal by dioxetane–fluorophore conjugates: turn-on chemiluminescence probes with color modulation for sensing and imaging
Mizusawa et al. Specific cell surface protein imaging by extended self-assembling fluorescent turn-on nanoprobes
Xu et al. Mitochondria-targeted fluorescent probe for imaging hydrogen peroxide in living cells
Li et al. Polarity-sensitive cell membrane probe reveals lower polarity of tumor cell membrane and its application for tumor diagnosis
Silvers et al. Profluorogenic reductase substrate for rapid, selective, and sensitive visualization and detection of human cancer cells that overexpress NQO1
Wen et al. Pinpoint diagnostic kit for heat stroke by monitoring lysosomal pH
Usama et al. Norcyanine-carbamates are versatile near-infrared fluorogenic probes
Wang et al. Ratiometric near-infrared fluorescent probe for synergistic detection of monoamine oxidase B and its contribution to oxidative stress in cell and mice aging models
Yang et al. Substrate-photocaged enzymatic fluorogenic probe enabling sequential activation for light-controllable monitoring of intracellular tyrosinase activity
Wen et al. Mitochondria-directed fluorescent probe for the detection of hydrogen peroxide near mitochondrial DNA
Ou-Yang et al. Detecting and imaging of γ-glutamytranspeptidase activity in serum, live cells, and pathological tissues with a high signal-stability probe by releasing a precipitating fluorochrome
Kong et al. An ultrasensitivity fluorescent probe based on the ict-fret dual mechanisms for imaging β-galactosidase in vitro and ex vivo
Chen et al. Near-infrared fluorescent and photoacoustic dual-mode probe for highly sensitive and selective imaging of cysteine in vivo
Liu et al. Real-time in situ visualizing of the sequential activation of caspase cascade using a multicolor gold–selenium bonding fluorescent nanoprobe
Hu et al. A golgi-targeting and dual-color “turn-on” probe for spatially precise imaging of furin