[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Frese Jr et al., 1994 - Google Patents

Targeting of genes to the liver with glycoprotein carriers

Frese Jr et al., 1994

Document ID
1387261535115098778
Author
Frese Jr J
Wu C
Wu G
Publication year
Publication venue
Advanced drug delivery reviews

External Links

Snippet

Several techniques are available to deliver foreign genes to cells in vitro. These techniques have offered valuable insights into gene regulation and expression. Many of these methods, however, have limited in vivo potential for clinical gene therapy because they compromise …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
    • A61K47/48Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
    • A61K47/48238Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the modifying agent being a protein, peptide, polyamino acid
    • A61K47/48246Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the modifying agent being a protein, peptide, polyamino acid drug-peptide, protein or polyamino acid conjugates, i.e. the modifying agent being a protein, peptide, polyamino acid which being linked/complexed to a molecule that being the pharmacologically or therapeutically active agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
    • A61K47/48Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
    • A61K47/48369Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the modifying part being an antibody, an immunoglobulin, or a fragment thereof, e.g. a Fc-fragment
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Similar Documents

Publication Publication Date Title
Frese Jr et al. Targeting of genes to the liver with glycoprotein carriers
Perales et al. An evaluation of receptor‐mediated gene transfer using synthetic DNA‐ligand complexes
Guy et al. Delivery of DNA into mammalian cells by receptor-mediated endocytosis and gene therapy
Boeckle et al. Melittin analogs with high lytic activity at endosomal pH enhance transfection with purified targeted PEI polyplexes
Plank et al. Gene transfer into hepatocytes using asialoglycoprotein receptor mediated endocytosis of DNA complexed with an artificial tetra-antennary galactose ligand
Erbacher et al. Glycosylated polylysine/DNA complexes: gene transfer efficiency in relation with the size and the sugar substitution level of glycosylated polylysines and with the plasmid size
Merwin et al. Targeted delivery of DNA using YEE (GalNAcAH) 3, a synthetic glycopeptide ligand for the asialoglycoprotein receptor
CA2012311C (en) New protein-polycation-conjugate
Kircheis et al. Coupling of cell-binding ligands to polyethylenimine for targeted gene delivery
US6177554B1 (en) Nucleic acid transporter systems
US5166320A (en) Carrier system and method for the introduction of genes into mammalian cells
Li et al. Targeted gene delivery to pulmonary endothelium by anti-PECAM antibody
US5994109A (en) Nucleic acid transporter system and methods of use
CA2103371C (en) Targeted delivery of genes encoding secretory proteins
Boeckle et al. Optimizing targeted gene delivery: chemical modification of viral vectors and synthesis of artificial virus vector systems
AU683400B2 (en) Use of a bacterial component to enhance targeted delivery of polynucleotides to cells
Han et al. Specific gene transfer mediated by galactosylated poly-L-lysine into hepatoma cells
Niidome et al. Gene transfer into hepatoma cells mediated by galactose-modified α-helical peptides
Rojanasakul et al. Targeted gene delivery to alveolar macrophages via Fc receptor-mediated endocytosis
WO1994006923A1 (en) Modification of a virus to redirect infectivity and enhance targeted delivery of polynucleotides to cells
Koyo et al. Effect of electric charge on the hepatic uptake of macromolecules in the rat liver
Mustapa et al. Stabilized integrin-targeting ternary LPD (lipopolyplex) vectors for gene delivery designed to disassemble within the target cell
Deshpande et al. Receptor-mediated peptide delivery in pulmonary epithelial monolayers
Fabre et al. Synthetic peptides as non-viral DNA vectors
Chiou et al. In vivo gene therapy via receptor-mediated dna delivery