[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Hartmann et al., 2000 - Google Patents

Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo

Hartmann et al., 2000

Document ID
13605880313765700006
Author
Hartmann G
Weeratna R
Ballas Z
Payette P
Blackwell S
Suparto I
Rasmussen W
Waldschmidt M
Sajuthi D
Purcell R
Davis H
Krieg A
Publication year
Publication venue
The Journal of Immunology

External Links

Snippet

Oligodeoxynucleotides (ODN) containing unmethylated CpG dinucleotides within specific sequence contexts (CpG motifs) are detected, like bacterial or viral DNA, as a danger signal by the vertebrate immune system. CpG ODN synthesized with a nuclease-resistant …
Continue reading at journals.aai.org (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure

Similar Documents

Publication Publication Date Title
Hartmann et al. Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo
AU776268B2 (en) Immunostimulant oligonucleotide
Krieg CpG motifs in bacterial DNA and their immune effects
Hartmann et al. Mechanism and function of a newly identified CpG DNA motif in human primary B cells
Vollmer et al. Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll‐like receptor 9 dependent T helper type 2 biased immune stimulation
Krieg Therapeutic potential of Toll-like receptor 9 activation
Davis et al. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen
Yi et al. Cutting edge: rapid induction of mitogen-activated protein kinases by immune stimulatory CpG DNA
Verthelyi et al. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
CA2270345C (en) Immunostimulatory nucleic acid molecules
Kamstrup et al. Response of porcine peripheral blood mononuclear cells to CpG-containing oligodeoxynucleotides
US7223741B2 (en) Immunostimulatory nucleic acid molecules
US7524828B2 (en) Immunostimulatory nucleic acid molecules
CN101460620B (en) Immunostimulatory oligonucleotide and pharmaceutical application thereof
PT1511845E (en) Immunostimulatory oligonucleotides and uses thereof
CN102517292A (en) Immunostimulatory oligoribonucleotides
Lipford et al. Poly‐guanosine motifs costimulate antigen‐reactive CD8 T cells while bacterial CpG‐DNA affect T‐cell activation via antigen‐presenting cell‐derived cytokines
CN101821392B (en) RNA sequence motifs in the context of defined inter-nucleotide linkages inducing specific immune modulatory profiles
Dong et al. An immunostimulatory oligodeoxynucleotide containing a cytidine-guanosine motif protects senescence-accelerated mice from lethal influenza virus by augmenting the T helper type 1 response
Bhagat et al. CpG penta-and hexadeoxyribonucleotides as potent immunomodulatory agents
EP1657307A1 (en) Oligonucleotides that induce the secretion of GM-CSF
CN1688192B (en) Immunostimulatory nucleic acids
Vitro Delineation of a CpG Phosphorothioate
CN101331229B (en) Immunostimulatory oligoribonucleotides
Ayash-Rashkovsky et al. TLR9 expression is related to immune activation but is impaired in individuals with chronic immune activation