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Gisbert-Garzarán et al., 2021 - Google Patents

Designing mesoporous silica nanoparticles to overcome biological barriers by incorporating targeting and endosomal escape

Gisbert-Garzarán et al., 2021

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Document ID
13697507322371279844
Author
Gisbert-Garzarán M
Lozano D
Matsumoto K
Komatsu A
Manzano M
Tamanoi F
Vallet-Regí M
Publication year
Publication venue
ACS applied materials & interfaces

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Snippet

The several biological barriers that nanoparticles might encounter when administered to a patient constitute the major bottleneck of nanoparticle-mediated tumor drug delivery, preventing their successful translation into the clinic and reducing their therapeutic profile. In …
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
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