Michels, 2022 - Google Patents
Precision crosslinking and active-site modifications via site-specific protein engineeringMichels, 2022
View PDF- Document ID
- 1341019634356694685
- Author
- Michels A
- Publication year
- Publication venue
- PQDT-Global
External Links
Snippet
Protein engineering promises to enable rationally designed constructs composed of endogenous or enhanced protein components with properties far beyond the individual components themselves or the capabilities of raw chemical synthesis. Such constructs have …
- 102000004169 proteins and genes 0 title abstract description 235
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/48—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP7075678B2 (en) | Peptide ligase and its use | |
CN108602878B (en) | C-terminal lysine conjugated immunoglobulins | |
JP6321658B2 (en) | Amino acid derivatives | |
US7838629B2 (en) | Ubiquitin or gamma-crystalline conjugates for use in therapy, diagnosis and chromatography | |
JP6343604B2 (en) | Method for incorporating amino acid containing BCN group into polypeptide using orthogonal codon encoding amino acid containing BCN group and orthogonal PylRS synthase | |
CN110709412A (en) | Protein and peptide tags with increased rate of spontaneous isopeptide bond formation and uses thereof | |
CN116199733A (en) | Method and product for fusion protein synthesis | |
JP2014525904A (en) | Using sortase to install click chemistry handles for protein ligation | |
EP3030545A2 (en) | Amino acid derivatives | |
Fernandes et al. | Engineered protein variants for bioconjugation | |
Pane et al. | Chemical cleavage of an Asp-Cys sequence allows efficient production of recombinant peptides with an N-terminal cysteine residue | |
CN106164263B (en) | Cyclopropene amino acids and methods | |
WO2011024887A1 (en) | Conjugate containing cyclic peptide and method for producing same | |
Michels | Precision crosslinking and active-site modifications via site-specific protein engineering | |
Plaks et al. | Lipoic acid ligase-promoted bioorthogonal protein modification and immobilization | |
Eddins et al. | Truncation-free genetic code expansion with tetrazine amino acids for quantitative protein ligations | |
Munoz-Robles et al. | Irreversible light-activated SpyLigation mediates split-protein assembly in 4D | |
Merten et al. | Facile site-specific multiconjugation strategies in recombinant proteins produced in bacteria | |
US20230313180A1 (en) | Multimeric antibody platform and methods of making and using multimeric antibody platform | |
Sornay et al. | Investigating Multicomponent Approaches for the Site-Selective Conjugation of Native Proteins | |
Howard | Expanding the Toolbox with Site-Specific Methods of Bioconjugation | |
CN115093376A (en) | Double/multiple functional unnatural amino acid, conjugate and application thereof | |
Wang et al. | Post-translational site-specific protein azidolation with an azido pyridoxal derivative | |
Kugler | Investigation of Peptidic Templates for Bioorthogonal Ligations | |
Brabham | O is for aldehyde: using pyrrolysine analogues to introduce reactive carbonyls into proteins for bioconjugation |