[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Sabourin et al., 1989 - Google Patents

Effect of exposure concentration, exposure rate, and route of administration on metabolism of benzene by F344 rats and B6C3F1 mice

Sabourin et al., 1989

Document ID
13116504310488890393
Author
Sabourin P
Bechtold W
Griffith W
Birnbaum L
Lucier G
Henderson R
Publication year
Publication venue
Toxicology and applied pharmacology

External Links

Snippet

To determine the effect of exposure concentration and the route of administration on benzene metabolism, male F 344 N rats and B6C3F1 mice were orally exposed to 1, 10, and 200 mg benzene/kg, and by inhalation for 6 hr to 5, 50, and 600 ppm benzene vapor. The …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline

Similar Documents

Publication Publication Date Title
Sabourin et al. Effect of exposure concentration, exposure rate, and route of administration on metabolism of benzene by F344 rats and B6C3F1 mice
Sabourin et al. Differences in the metabolism and disposition of inhaled [3H] benzene by F344N rats and B6C3F1 mice
Murray et al. Paraquat disposition in rats, guinea pigs and monkeys
WALLIN et al. Sevoflurane: a new inhalational anesthetic agent
Watanabe et al. Fate of [14C] vinyl chloride following inhalation exposure in rats
Henderson et al. The effect of dose, dose rate, route of administration, and species on tissue and blood levels of benzene metabolites.
Bechtold et al. Muconic acid determinations in urine as a biological exposure index for workers occupationally exposed to benzene
Koss et al. Studies on the toxicology of hexachlorobenzene: II. Identification and determination of metabolites
Bergman et al. Application and results of whole-body autoradiography in distribution studies of organic solvents
Leuschner et al. Pharmacokinetics of delta 9-tetrahydrocannabinol in rabbits following single or multiple intravenous doses.
Schaefer et al. Distribution of synthetic cannabinoids JWH-210, RCS-4 and Δ 9-tetrahydrocannabinol after intravenous administration to pigs
US4223004A (en) Drug compositions
Timchalk et al. Route-dependent comparative metabolism of [14C] toluene 2, 4-diisocyanate and [14C] toluene 2, 4-diamine in Fischer 344 rats
Wilson et al. Uptake, metabolism and efflux of methadone in" single pass" isolated perfused rabbit lungs.
McKenna et al. The pharmacokinetics of [14C] vinylidene chloride in rats following inhalation exposure
Kenyon et al. Differences in rates of benzene metabolism correlate with observed genotoxicity
Døssing Noninvasive assessment of microsomal enzyme activity in occupational medicine: present state of knowledge and future perspectives
Segerback et al. In vivo tissue dosimetry as a basis for cross-species extrapolation in cancer risk assessment of propylene oxide
Sun et al. Benzene hemoglobin adducts in mice and rats: characterization of formation and physiological modeling
Bilimoria et al. Protective antioxidant mechanisms in rat and guinea pig tissues challenged by acute exposure to cigarette smoke
Edgar Cook et al. Phencyclidine and phenylcyclohexene disposition after smoking phencyclidine
Bond et al. Metabolism and macromolecular covalent binding of [14C]-1-nitropyrene in isolated perfused and ventilated rat lungs
Morgan et al. Styrene Inhalation Toxicity Studies in Mice: III. Strain Differences in Susceptibility
Mitchell et al. Involvement of the polyamine transport system in cellular uptake of the radioprotectants WR-1065 and WR-33278
Kaye et al. The plasma pharmacokinetics and tissue distribution of dimethyl sulfoxide in mice