[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Rodríguez-Hernández et al., 2015 - Google Patents

Hederagenin as a triterpene template for the development of new antitumor compounds

Rodríguez-Hernández et al., 2015

Document ID
1316375173947728171
Author
Rodríguez-Hernández D
Demuner A
Barbosa L
Csuk R
Heller L
Publication year
Publication venue
European Journal of Medicinal Chemistry

External Links

Snippet

In this study, a series of novel C-28 esters and amides derivatives of hederagenin (He) were designed and synthesized in attempt to develop potent antitumor agents. Their structures were confirmed by MS, IR, 1 H NMR and 13 C NMR spectroscopic analyses and their …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2103/00—Systems containing at least three condensed rings
    • C07C2103/02—Ortho- or ortho- and peri-condensed systems
    • C07C2103/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2103/22—Ortho- or ortho- and peri-condensed systems containing three rings containing only six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2103/00—Systems containing at least three condensed rings
    • C07C2103/02—Ortho- or ortho- and peri-condensed systems
    • C07C2103/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2103/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2103/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0036—Nitrogen-containing hetero ring
    • C07J71/0042—Nitrogen only
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton

Similar Documents

Publication Publication Date Title
Rodríguez-Hernández et al. Hederagenin as a triterpene template for the development of new antitumor compounds
Chiang et al. Cytotoxic triterpenes from the aerial roots of Ficus microcarpa
Begum et al. Carandinol: First isohopane triterpene from the leaves of Carissa carandas L. and its cytotoxicity against cancer cell lines
Ren et al. Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives
Yousuf et al. Ring A structural modified derivatives of withaferin A and the evaluation of their cytotoxic potential
Csuk et al. Synthesis and biological activity of some antitumor active derivatives from glycyrrhetinic acid
Parra et al. Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells
Csuk et al. Synthesis and antitumor activity of ring A modified 11-keto-β-boswellic acid derivatives
He et al. Hepatoprotective triterpenes from Sedum sarmentosum
Qi et al. Cytotoxicity and structure activity relationships of phytosterol from Phyllanthus emblica
Topçu et al. Ovarian antiproliferative activity directed isolation of triterpenoids from fruits of Eucalyptus camaldulensis Dehnh
Mallavadhani et al. Synthesis and anti-cancer activity of some novel C-17 analogs of ursolic and oleanolic acids
Efdi et al. Sentulic acid: A cytotoxic ring A-seco triterpenoid from Sandoricum koetjape Merr
Maldonado et al. Philadelphicalactones C and D and other cytotoxic compounds from Physalis philadelphica
Salomatina et al. Synthesis of novel 2-cyano substituted glycyrrhetinic acid derivatives as inhibitors of cancer cells growth and NO production in LPS-activated J-774 cells
Choudhary et al. Chlorinated and diepoxy withanolides from Withania somnifera and their cytotoxic effects against human lung cancer cell line
Srivastava et al. New anti-inflammatory triterpene from the root of Ricinus communis
Thuong et al. Symmetric dimers of ent-kaurane diterpenoids with cytotoxic activity from Croton tonkinensis
Bednarczyk-Cwynar et al. Oleanolic acid A-lactams inhibit the growth of HeLa, KB, MCF-7 and Hep-G2 cancer cell lines at micromolar concentrations
Ali et al. Evaluation of the cytotoxic potential of a new pentacyclic triterpene from Rhododendron arboreum stem bark
Farheen et al. Triterpenoids and triterpenoid saponins from the aerial parts of Fagonia indica Burm
Gao et al. Kadcoccilactones K–R, triterpenoids from Kadsura coccinea
Cheng et al. New alkaloids from Formosan zoanthid Zoanthus kuroshio
Li et al. Triterpenoids with anti-proliferative effects from the seeds of Peganum harmala L.
Pattnaik et al. Synthesis of ring-C modified oleanolic acid derivatives and their cytotoxic evaluation