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Fallerini et al., 2021 - Google Patents

Association of Toll-like receptor 7 variants with life-threatening COVID-19 disease in males: findings from a nested case-control study

Fallerini et al., 2021

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Document ID
12708055934290102717
Author
Fallerini C
Daga S
Mantovani S
Benetti E
Picchiotti N
Francisci D
Paciosi F
Schiaroli E
Baldassarri M
Fava F
Palmieri M
Ludovisi S
Castelli F
Quiros-Roldan E
Vaghi M
Rusconi S
Siano M
Bandini M
Spiga O
Capitani K
Furini S
Mari F
GEN-COVID Multicenter Study Valentino Floriana Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Doddato Gabriella Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Giliberti Annarita Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Tita Rossella Genetica Medica, Azienda Ospedaliero-Universitaria Senese Siena Italy Amitrano Sara Genetica Medica, Azienda Ospedaliero-Universitaria Senese Siena Italy Bruttini Mirella Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Genetica Medica, Azienda Ospedaliero-Universitaria Senese Siena Italy Croci Susanna Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Meloni Ilaria Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Mencarelli Maria Antonietta Genetica Medica, Azienda Ospedaliero-Universitaria Senese Siena Italy Lo Rizzo Caterina Genetica Medica, Azienda Ospedaliero-Universitaria Senese Siena Italy Pinto Anna Maria Genetica Medica, Azienda Ospedaliero-Universitaria Senese Siena Italy Di Sarno Laura Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Beligni Giada Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Tommasi Andrea Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Genetica Medica, Azienda Ospedaliero-Universitaria Senese Siena Italy Iuso Nicola Medical Genetics, University of Siena Siena Italy Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Montagnani Francesca Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Dept of Specialized and Internal Medicine, Tropical and Infectious Diseases Unit, Azienda Ospedaliera Universitaria Senese Siena Italy Fabbiani Massimiliano Dept of Specialized and Internal Medicine, Tropical and Infectious Diseases Unit, Azienda Ospedaliera Universitaria Senese Siena Italy Rossetti Barbara Dept of Specialized and Internal Medicine, Tropical and Infectious Diseases Unit, Azienda Ospedaliera Universitaria Senese Siena Italy Zanelli Giacomo Med Biotech Hub and Competence Center, Department of Medical Biotechnologies, University of Siena Siena Italy Dept of Specialized and Internal Medicine, Tropical and Infectious Diseases Unit, Azienda Ospedaliera Universitaria Senese Siena Italy Bargagli Elena Unit of Respiratory Diseases and Lung Transplantation, Department of Internal and Specialist Medicine, University of Siena Siena Italy Bergantini Laura Unit of Respiratory Diseases and Lung Transplantation, Department of Internal and Specialist Medicine, University of Siena Siena Italy D’Alessandro Miriana Unit of Respiratory Diseases and Lung Transplantation, Department of Internal and Specialist Medicine, University of Siena Siena Italy Cameli Paolo Unit of Respiratory Diseases and Lung Transplantation, Department of Internal and Specialist Medicine, University of Siena Siena Italy Bennett David Unit of Respiratory Diseases and Lung Transplantation, Department of Internal and Specialist Medicine, University of Siena Siena Italy Anedda Federico Dept of Emergency and Urgency, Medicine, Surgery and Neurosciences, Unit of Intensive Care Medicine, Siena University Hospital Siena Italy Marcantonio Simona Dept of Emergency and Urgency, Medicine, Surgery and Neurosciences, Unit of Intensive Care Medicine, Siena University Hospital Siena Italy Scolletta Sabino Dept of Emergency and Urgency, Medicine, Surgery and Neurosciences, Unit of Intensive Care Medicine, Siena University Hospital Siena Italy Franchi Federico Dept of Emergency and Urgency, Medicine, Surgery and Neurosciences, Unit of Intensive Care Medicine, Siena University Hospital Siena Italy Mazzei Maria Antonietta Department of Medical, Surgical and Neuro Sciences and Radiological Sciences, Unit of Diagnostic Imaging, University of Siena Siena Italy Guerrini Susanna Department of Medical, Surgical and Neuro Sciences and Radiological Sciences, Unit of Diagnostic Imaging, University of Siena Siena Italy Conticini Edoardo Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte Siena Italy Cantarini Luca Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte Siena Italy Frediani Bruno Rheumatology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte Siena Italy Tacconi Danilo Department of Specialized and Internal Medicine, Infectious Diseases Unit, San Donato Hospital Arezzo, San Donato Hospital Arezzo Arezzo Italy Spertilli Chiara Department of Specialized and Internal Medicine, Infectious Diseases Unit, San Donato Hospital Arezzo, San Donato Hospital Arezzo Arezzo Italy Feri Marco Dept of Emergency, Anesthesia Unit, San Donato Hospital Arezzo Italy Donati Alice Dept of Emergency, Anesthesia Unit, San Donato Hospital Arezzo Italy Scala Raffaele Department of Specialized and Internal Medicine, Pneumology Unit and UTIP, San Donato Hospital Arezzo Italy Guidelli Luca Department of Specialized and Internal Medicine, Pneumology Unit and UTIP, San Donato Hospital Arezzo Italy Spargi Genni Department of Emergency, Anesthesia Unit, Misericordia Hospital Grosseto Italy Corridi Marta Department of Emergency, Anesthesia Unit, Misericordia Hospital Grosseto Italy Nencioni Cesira Department of Specialized and Internal Medicine, Infectious Diseases Unit, Misericordia Hospital Grosseto Italy Croci Leonardo Department of Specialized and Internal Medicine, Infectious Diseases Unit, Misericordia Hospital Grosseto Italy Caldarelli Gian Piero Clinical Chemical Analysis Laboratory, Misericordia Hospital Grosseto Italy Spagnesi Maurizio Department of Preventive Medicine, Azienda USL Toscana Sud Est Siena Italy Romani Davide Department of Preventive Medicine, Azienda USL Toscana Sud Est Siena Italy Piacentini Paolo Department of Preventive Medicine, Azienda USL Toscana Sud Est Siena Italy Desanctis Elena Department of Preventive Medicine, Azienda USL Toscana Sud Est Siena Italy Cappelli Silvia Department of Preventive Medicine, Azienda USL Toscana Sud Est Siena Italy Canaccini Anna Territorial Scientific Technician Department, Azienda USL Toscana Sud Est Siena Italy Verzuri Agnese Territorial Scientific Technician Department, Azienda USL Toscana Sud Est Siena Italy Anemoli Valentina Territorial Scientific Technician Department, Azienda USL Toscana Sud Est Siena Italy Ognibene Agostino Clinical Chemical Analysis Laboratory, San Donato Hospital Arezzo Italy Monforte Antonella D’Arminio Department of Health Sciences, Clinic of Infectious Diseases, ASST Santi Paolo e Carlo, University of Milan Milano Italy Miraglia Federica Gaia Department of Health Sciences, Clinic of Infectious Diseases, ASST Santi Paolo e Carlo, University of Milan Milano Italy Girardis Massimo Department of Anesthesia and Intensive Care, University of Modena and Reggio Emilia Modena Italy Venturelli Sophie Department of Anesthesia and Intensive Care, University of Modena and Reggio Emilia Modena Italy Busani Stefano Department of Anesthesia and Intensive Care, University of Modena and Reggio Emilia Modena Italy Cossarizza Andrea Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia Modena Italy Antinori Andrea HIV/AIDS Department, National Institute for Infectious Diseases, IRCCS, Lazzaro Spallanzani Rome Italy Vergori Alessandra HIV/AIDS Department, National Institute for Infectious Diseases, IRCCS, Lazzaro Spallanzani Rome Italy Emiliozzi Arianna HIV/AIDS Department, National Institute for Infectious Diseases, IRCCS, Lazzaro Spallanzani Rome Italy Gabrieli Arianna Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan Milan Italy Riva Agostino III Infectious Diseases Unit, ASST-FBF-Sacco Milan Italy Department of Biomedical and Clinical Sciences Luigi Sacco, University of Milan Milan Italy Scotton Pier Giorgio Department of Infectious Diseases, Treviso Hospital, Local Health Unit 2 Marca Trevigiana Treviso Italy Andretta Francesca Department of Infectious Diseases, Treviso Hospital, Local Health Unit 2 Marca Trevigiana Treviso Italy Panese Sandro Clinical Infectious Diseases, Mestre Hospital Venezia Italy Scaggiante Renzo Infectious Diseases Clinic, ULSS1 Belluno Italy Gatti Francesca Infectious Diseases Clinic, ULSS1 Belluno Italy Parisi Saverio Giuseppe Department of Molecular Medicine, University of Padova Padua Italy Baratti Stefano Department of Molecular Medicine, University of Padova Padua Italy Antoni Melania Degli Department of Infectious and Tropical Diseases, University of Brescia and ASST Spedali Civili Hospital Brescia Italy Monica Matteo Della Medical Genetics and Laboratory of Medical Genetics Unit, AORN" Antonio Cardarelli" Naples Italy Piscopo Carmelo Medical Genetics and Laboratory of Medical Genetics Unit, AORN" Antonio Cardarelli" Naples Italy Capasso Mario Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II Naples Italy CEINGE Biotecnologie Avanzate Naples Italy IRCCS SDN Naples Italy Russo Roberta Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II Naples Italy CEINGE Biotecnologie Avanzate Naples Italy Andolfo Immacolata Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II Naples Italy CEINGE Biotecnologie Avanzate Naples Italy Iolascon Achille Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II Naples Italy CEINGE Biotecnologie Avanzate Naples Italy Fiorentino Giuseppe Unit of Respiratory Physiopathology, AORN dei Colli, Monaldi Hospital Naples Italy Carella Massimo Division of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo San Giovanni Rotondo Italy Castori Marco Division of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo San Giovanni Rotondo Italy Merla Giuseppe Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II Naples Italy Laboratory of Regulatory and Functional Genomics, Fondazione IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo Italy Squeo Gabriella Maria Laboratory of Regulatory and Functional Genomics, Fondazione IRCCS Casa Sollievo della Sofferenza San Giovanni Rotondo Italy Aucella Filippo Department of Medical Sciences, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo San Giovanni Rotondo Italy Raggi Pamela Clinical Trial Office, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo San Giovanni Rotondo Italy Marciano Carmen Clinical Trial Office, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo San Giovanni Rotondo Italy Perna Rita Clinical Trial Office, Fondazione IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo San Giovanni Rotondo Italy Bassetti Matteo Department of Health Sciences, University of Genova Genova Italy Infectious Diseases Clinic, Policlinico San Martino Hospital, IRCCS for Cancer Research Genova Genova Italy Di Biagio Antonio Infectious Diseases Clinic, Policlinico San Martino Hospital, IRCCS for Cancer Research Genova Genova Italy Sanguinetti Maurizio Microbiology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University of Medicine Rome Italy Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Masucci Luca Microbiology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Catholic University of Medicine Rome Italy Department of Laboratory Sciences and Infectious Diseases, Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy Valente Serafina Department of Cardiovascular Diseases, University of Siena Siena Italy Mandalà Marco Otolaryngology Unit, University of Siena Siena Italy Giorli Alessia Otolaryngology Unit, University of Siena Siena Italy Salerni Lorenzo Otolaryngology Unit, University of Siena Siena Italy Zucchi Patrizia Department of Internal Medicine, ASST Valtellina e Alto Lario Sondrio Italy Parravicini Pierpaolo Department of Internal Medicine, ASST Valtellina e Alto Lario Sondrio Italy Menatti Elisabetta Study Coordinator Oncologia Medica e Ufficio Flussi Sondrio Sondrio Italy Trotta Tullio First Aid Department, Luigi Curto Hospital, Polla Salerno Italy Giannattasio Ferdinando First Aid Department, Luigi Curto Hospital, Polla Salerno Italy Coiro Gabriella First Aid Department, Luigi Curto Hospital, Polla Salerno Italy Lena Fabio Local Health Unit-Pharmaceutical Department of Grosseto, Toscana Sud Est Local Health Unit Grosseto Italy Coviello Domenico A UOC Laboratorio di Genetica Umana, IRCCS Istituto G. Gaslini Genova Italy Mussini Cristina Infectious Diseases Clinics, University of Modena and Reggio Emilia Modena Italy Bosio Giancarlo Department of Respiratory Diseases, Azienda Ospedaliera di Cremona Cremona Italy Martinelli Enrico Department of Respiratory Diseases, Azienda Ospedaliera di Cremona Cremona Italy Mancarella Sandro UOC Medicina, ASST Nord Milano, Ospedale Bassini Cinisello Balsamo Italy Tavecchia Luisa UOC Medicina, ASST Nord Milano, Ospedale Bassini Cinisello Balsamo Italy Gori Marco Université Côte d’Azur Inria France Crotti Lia Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital Milan Italy Department of Medicine and Surgery, University of Milano-Bicocca Milan Italy Istituto Auxologico Italiano, IRCCS, Center for Cardiac Arrhythmias of Genetic Origin Milan Italy Istituto Auxologico Italiano, IRCCS, Laboratory of Cardiovascular Genetics Milan Italy Member of the European Reference Network for Rare, Low Prevalence and Complex Diseases of the Heart-ERN GUARD-Heart Parati Gianfranco Istituto Auxologico Italiano, IRCCS, Department of Cardiovascular, Neural and Metabolic Sciences, San Luca Hospital Milan Italy Department of Medicine and Surgery, University of Milano-Bicocca Milan Italy Gabbi Chiara Independent Medical Scientist Milan Italy Zanella Isabella Department of Molecular and Translational Medicine, University of Brescia Brescia Italy Clinical Chemistry Laboratory, Cytogenetics and Molecular Genetics Section, Diagnostic Department, ASST Spedali Civili di Brescia Brescia Italy Rizzi Marco Unit of Infectious Diseases, ASST Papa Giovanni XXIII Hospital Bergamo Italy Maggiolo Franco Unit of Infectious Diseases, ASST Papa Giovanni XXIII Hospital Bergamo Italy Ripamonti Diego Unit of Infectious Diseases, ASST Papa Giovanni XXIII Hospital Bergamo Italy Bachetti Tiziana Direzione Scientifica, Istituti Clinici Scientifici Maugeri IRCCS Pavia Italy La Rovere Maria Teresa Istituti Clinici Scientifici Maugeri IRCCS, Department of Cardiology, Institute of Montescano Pavia Italy Sarzi-Braga Simona Istituti Clinici Scientifici Maugeri, IRCCS, Department of Cardiac Rehabilitation, Institute of Tradate (VA) Tradate Italy Bussotti Maurizio Istituti Clinici Scientifici Maugeri, IRCCS, Department of Cardiac Rehabilitation, Institute of Milan Milan Italy Chiariello Mario Istituto per lo Studio, la Prevenzione e la Rete Oncologica (ISPRO)-Core Research Laboratory and Consiglio Nazionale delle Ricerche-Istituto di Fisiologia Clinica Siena Italy Belli Mary Ann ASST Nord Milano, Ospedale Bassini Cinisello Balsamo Italy Dei Simona Health Management, Azienda USL Toscana Sudest Tuscany Italy
Renieri A
Mondelli M
Frullanti E
Publication year
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Background: Recently, loss-of-function variants in TLR7 were identified in two families in which COVID-19 segregates like an X-linked recessive disorder environmentally conditioned by SARS-CoV-2. We investigated whether the two families represent the tip of …
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    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING; COUNTING
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    • G06F19/00—Digital computing or data processing equipment or methods, specially adapted for specific applications
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