Kalinina et al., 2021 - Google Patents
Amelioration of graft-versus-host disease by exopolysaccharide from a commensal bacteriumKalinina et al., 2021
- Document ID
- 12654967224438549660
- Author
- Kalinina O
- Talley S
- Zamora-Pineda J
- Paik W
- Campbell E
- Knight K
- Publication year
- Publication venue
- The Journal of Immunology
External Links
Snippet
Acute graft-versus-host disease (aGvHD) is a severe, often lethal, complication of hematopoietic stem cell transplantation, and although prophylactic regimens are given as standard pretransplantation therapy, up to 60% of these patients develop aGvHD, and …
- 229920002444 Exopolysaccharide 0 title abstract description 166
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Micro-organisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5063—Compounds of unknown constitution, e.g. material from plants or animals
- A61K9/5068—Cell membranes or bacterial membranes enclosing drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Jain et al. | New insights into the cancer–microbiome–immune axis: decrypting a decade of discoveries | |
Cowley et al. | CD4− CD8− T cells control intracellular bacterial infections both in vitro and in vivo | |
Meierovics et al. | MAIT cells promote inflammatory monocyte differentiation into dendritic cells during pulmonary intracellular infection | |
Blomgran et al. | Lung neutrophils facilitate activation of naive antigen-specific CD4+ T cells during Mycobacterium tuberculosis infection | |
Hu et al. | Maternal antibiotic treatment protects offspring from diabetes development in nonobese diabetic mice by generation of tolerogenic APCs | |
Green et al. | IFN-γ from CD4 T cells is essential for host survival and enhances CD8 T cell function during Mycobacterium tuberculosis infection | |
Tian et al. | In vivo depletion of CD11c+ cells delays the CD4+ T cell response to Mycobacterium tuberculosis and exacerbates the outcome of infection | |
Askenase et al. | Bone-marrow-resident NK cells prime monocytes for regulatory function during infection | |
Srivastava et al. | Cutting edge: Direct recognition of infected cells by CD4 T cells is required for control of intracellular Mycobacterium tuberculosis in vivo | |
Debbabi et al. | Primary type II alveolar epithelial cells present microbial antigens to antigen-specific CD4+ T cells | |
Ochoa-Repáraz et al. | Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression | |
Wolf et al. | Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo | |
D’Souza et al. | Mucosal-associated invariant T cells augment immunopathology and gastritis in chronic Helicobacter pylori infection | |
Simmons et al. | Mycobacterium tuberculosis and TLR2 agonists inhibit induction of type I IFN and class I MHC antigen cross processing by TLR9 | |
Engel et al. | Tumor necrosis factor alpha-and inducible nitric oxide synthase-producing dendritic cells are rapidly recruited to the bladder in urinary tract infection but are dispensable for bacterial clearance | |
JP6125041B2 (en) | Composition for treating cancer using bacteria and use of bacteria for its production | |
Kalinina et al. | Amelioration of graft-versus-host disease by exopolysaccharide from a commensal bacterium | |
Lin et al. | Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum | |
Langa et al. | Characterization of Lactobacillus salivarius CECT 5713, a strain isolated from human milk: from genotype to phenotype | |
Calcaterra et al. | Critical role of TLR9 in acute graft-versus-host disease | |
Mizobuchi et al. | Differential expression of Smad7 transcripts identifies the CD4+ CD45RChigh regulatory T cells that mediate type V collagen-induced tolerance to lung allografts | |
Romero et al. | The role of interferon-γ in the pathogenesis of acute intra-abdominal sepsis | |
Oh et al. | Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells | |
Gonzales et al. | Antibacterial role for natural killer cells in host defense to Bacillus anthracis | |
Loof et al. | The contribution of dendritic cells to host defenses against Streptococcus pyogenes |