Rutz et al., 2011 - Google Patents
Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cellsRutz et al., 2011
View PDF- Document ID
- 12436903412766189232
- Author
- Rutz S
- Noubade R
- Eidenschenk C
- Ota N
- Zeng W
- Zheng Y
- Hackney J
- Ding J
- Singh H
- Ouyang W
- Publication year
- Publication venue
- Nature immunology
External Links
Snippet
Abstract Interleukin 22 (IL-22), which is produced by cells of the TH17 subset of helper T cells and other leukocytes, not only enhances proinflammatory innate defense mechanisms in epithelial cells but also provides crucial protection to tissues from damage caused by …
- 102000007987 Proto-Oncogene Proteins c-maf 0 title abstract description 150
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Rutz et al. | Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells | |
Bruchard et al. | The receptor NLRP3 is a transcriptional regulator of TH2 differentiation | |
Yu et al. | CD69 enhances immunosuppressive function of regulatory T-cells and attenuates colitis by prompting IL-10 production | |
Lazarevic et al. | T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt | |
Geng et al. | The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells | |
Yoon et al. | Phosphorylation status determines the opposing functions of Smad2/Smad3 as STAT3 cofactors in TH17 differentiation | |
Tanaka et al. | Trim33 mediates the proinflammatory function of Th17 cells | |
Pietschke et al. | The inflammation in cutaneous lichen planus is dominated by IFN‐ϒ and IL‐21—A basis for therapeutic JAK1 inhibition | |
Mitchell et al. | IL-4 enhances IL-10 production in Th1 cells: implications for Th1 and Th2 regulation | |
Schmitt et al. | The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells | |
Wang et al. | Cutting edge: Smad2 and Smad4 regulate TGF-β–mediated Il9 gene expression via EZH2 displacement | |
Humblin et al. | IRF8-dependent molecular complexes control the Th9 transcriptional program | |
Nakatsukasa et al. | The DNA-binding inhibitor Id3 regulates IL-9 production in CD4+ T cells | |
Liao et al. | Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages | |
Volpe et al. | A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses | |
Zhang et al. | Tumor cell-intrinsic Tim-3 promotes liver cancer via NF-κB/IL-6/STAT3 axis | |
Ouyang et al. | Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation | |
Ji et al. | Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8+ T cells | |
Végran et al. | The transcription factor IRF1 dictates the IL-21-dependent anticancer functions of TH9 cells | |
Yoo et al. | Placental growth factor regulates the generation of TH17 cells to link angiogenesis with autoimmunity | |
Kuwahara et al. | The transcription factor Sox4 is a downstream target of signaling by the cytokine TGF-β and suppresses TH2 differentiation | |
Neumann et al. | Role of Blimp-1 in programing Th effector cells into IL-10 producers | |
Zhou et al. | IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways | |
Maruyama et al. | Control of the differentiation of regulatory T cells and TH17 cells by the DNA-binding inhibitor Id3 | |
Ichiyama et al. | Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*♦ |