Wysocki et al., 2000 - Google Patents
Mobile and localized protons: a framework for understanding peptide dissociationWysocki et al., 2000
View PDF- Document ID
- 12037354034216241227
- Author
- Wysocki V
- Tsaprailis G
- Smith L
- Breci L
- Publication year
- Publication venue
- Journal of Mass Spectrometry
External Links
Snippet
Protein identification and peptide sequencing by tandem mass spectrometry requires knowledge of how peptides fragment in the gas phase, specifically which bonds are broken and where the charge (s) resides in the products. For many peptides, cleavage at the amide …
- 238000010494 dissociation reaction 0 title abstract description 34
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- H—ELECTRICITY
- H01—BASIC ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometer or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
- H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Wysocki et al. | Mobile and localized protons: a framework for understanding peptide dissociation | |
| Paizs et al. | Fragmentation pathways of protonated peptides | |
| Harrison | To b or not to b: the ongoing saga of peptide b ions | |
| Reid et al. | ‘Top down’protein characterization via tandem mass spectrometry | |
| Beardsley et al. | Enhancing the intensities of lysine‐terminated tryptic peptide ions in matrix‐assisted laser desorption/ionization mass spectrometry | |
| Harrison et al. | Scrambling of sequence information in collision-induced dissociation of peptides | |
| Bleiholder et al. | Sequence-scrambling fragmentation pathways of protonated peptides | |
| Kruppa et al. | A top down approach to protein structural studies using chemical cross‐linking and Fourier transform mass spectrometry | |
| Kjeldsen et al. | Cα C Backbone Fragmentation Dominates in Electron Detachment Dissociation of Gas‐Phase Polypeptide Polyanions | |
| Wee et al. | Side‐chain radical losses from radical cations allows distinction of leucine and isoleucine residues in the isomeric peptides Gly‐XXX‐Arg | |
| Hurtado et al. | Differentiation of isomeric amino acid residues in proteins and peptides using mass spectrometry | |
| Lee et al. | Disulfide bond cleavage in TEMPO‐free radical initiated peptide sequencing mass spectrometry | |
| Reid et al. | Probing the fragmentation reactions of protonated glycine oligomers via multistage mass spectrometry and gas phase ion molecule hydrogen/deuterium exchange | |
| McGee et al. | The ornithine effect in peptide cation dissociation | |
| Kaltashov et al. | Crossing the phase boundary to study protein dynamics and function: combination of amide hydrogen exchange in solution and ion fragmentation in the gas phase | |
| Heeren et al. | A mini-review of mass spectrometry using high-performance FTICR-MS methods | |
| Takahashi et al. | Hydrogen attachment/abstraction dissociation (HAD) of gas-phase peptide ions for tandem mass spectrometry | |
| Joly et al. | Specific UV photodissociation of tyrosyl‐containing peptides in multistage mass spectrometry | |
| Cannon et al. | Characterization of green fluorescent proteins by 193 nm ultraviolet photodissociation mass spectrometry | |
| Asakawa | Principles of hydrogen radical mediated peptide/protein fragmentation during matrix‐assisted laser desorption/ionization mass spectrometry | |
| Enders et al. | Chiral and structural analysis of biomolecules using mass spectrometry and ion mobility‐mass spectrometry | |
| Kjeldsen et al. | Zwitterionic states in gas‐phase polypeptide ions revealed by 157‐nm ultra‐violet photodissociation | |
| Lau et al. | Observations on the detection of b‐and y‐type ions in the collisionally activated decomposition spectra of protonated peptides | |
| Mouls et al. | Tandem mass spectrometry of amidated peptides | |
| Olsen et al. | Comparison of electron capture dissociation and collisionally activated dissociation of polycations of peptide nucleic acids |