Shih et al., 2014 - Google Patents
Cracking the cytotoxicity code: Apoptotic induction of 10-acetylirciformonin B is mediated through ROS generation and mitochondrial dysfunctionShih et al., 2014
View HTML- Document ID
- 11877282617577184432
- Author
- Shih H
- El-Shazly M
- Juan Y
- Chang C
- Su J
- Chen Y
- Shih S
- Chen H
- Wu Y
- Lu M
- Publication year
- Publication venue
- Marine drugs
External Links
Snippet
A marine furanoterpenoid derivative, 10-acetylirciformonin B (10AB), was found to inhibit the proliferation of leukemia, hepatoma, and colon cancer cell lines, with selective and significant potency against leukemia cells. It induced DNA damage and apoptosis in …
- 230000001640 apoptogenic 0 title abstract description 41
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Shih et al. | Cracking the cytotoxicity code: Apoptotic induction of 10-acetylirciformonin B is mediated through ROS generation and mitochondrial dysfunction | |
| Wei et al. | Shikonin inhibits the proliferation of human breast cancer cells by reducing tumor-derived exosomes | |
| Wang et al. | The effects of autophagy and PI3K/AKT/m-TOR signaling pathway on the cell-cycle arrest of rats primary sertoli cells induced by zearalenone | |
| Lin et al. | Role of mitochondrial DNA copy number alteration in human renal cell carcinoma | |
| Liu et al. | Genistein enhances the radiosensitivity of breast cancer cells via G2/M cell cycle arrest and apoptosis | |
| Starenki et al. | Mortalin (GRP75/HSPA9) promotes survival and proliferation of thyroid carcinoma cells | |
| Dehghan Harati et al. | Nanog signaling mediates radioresistance in ALDH-positive breast cancer cells | |
| Song et al. | Kv3. 1 and Kv3. 4, are involved in cancer cell migration and invasion | |
| Shang et al. | Epigenetic targeting of Mcl-1 is synthetically lethal with Bcl-xL/Bcl-2 inhibition in model systems of glioblastoma | |
| Tortolici et al. | Ionizing radiation-induced extracellular vesicle release promotes AKT-associated survival response in SH-SY5Y neuroblastoma cells | |
| Feng et al. | Peruvoside, a cardiac glycoside, induces primitive myeloid leukemia cell death | |
| Lee et al. | Ursolic acid-induced apoptosis via regulation of the PI3K/Akt and MAPK signaling pathways in Huh-7 cells | |
| Lu et al. | Ovatodiolide inhibits breast cancer stem/progenitor cells through SMURF2-mediated downregulation of Hsp27 | |
| Bagchi et al. | Endoplasmic reticulum stress promotes iNOS/NO and influences inflammation in the development of doxorubicin-induced cardiomyopathy | |
| Shih et al. | Tackling the cytotoxic effect of a marine polycyclic quinone-type metabolite: Halenaquinone induces molt 4 cells apoptosis via oxidative stress combined with the inhibition of HDAC and topoisomerase activities | |
| Wang et al. | The antioxidant from ethanolic extract of Rosa cymosa fruits activates phosphatase and tensin homolog in vitro and in vivo: A new insight on its antileukemic effect | |
| Lovatt et al. | Regulation of oxidative stress in corneal endothelial cells by Prdx6 | |
| Pyrczak-Felczykowska et al. | The isoxazole derivative of usnic acid induces an ER stress response in breast cancer cells that leads to paraptosis-like cell death | |
| Nguyen et al. | Activation of LXR receptors and inhibition of TRAP1 causes synthetic lethality in solid tumors | |
| Lee et al. | CNOT2 is critically involved in atorvastatin induced apoptotic and autophagic cell death in non-small cell lung cancers | |
| Zhu et al. | L-cystathionine inhibits the mitochondria-mediated macrophage apoptosis induced by oxidized low density lipoprotein | |
| Beke Debreceni et al. | Dasatinib inhibits procoagulant and clot retracting activities of human platelets | |
| Mirzayans et al. | Spontaneous γH2AX foci in human solid tumor-derived cell lines in relation to p21WAF1 and WIP1 expression | |
| Bossio et al. | Oleuropein counteracts both the proliferation and migration of intra-and extragonadal seminoma cells | |
| Wu et al. | ALDH1-mediated autophagy sensitizes glioblastoma cells to ferroptosis |