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Pan et al., 2014 - Google Patents

A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency

Pan et al., 2014

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Document ID
11520674497068629628
Author
Pan D
Flores O
Umbach J
Pesola J
Bentley P
Rosato P
Leib D
Cullen B
Coen D
Publication year
Publication venue
Cell host & microbe

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After infecting peripheral sites, herpes simplex virus (HSV) invades the nervous system and initiates latent infection in sensory neurons. Establishment and maintenance of HSV latency require host survival, and entail repression of productive cycle (" lytic") viral gene …
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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