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Yoon et al., 2008 - Google Patents

Additive antinociception between intrathecal sildenafil and morphine in the rat formalin test

Yoon et al., 2008

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Document ID
1059844755590429449
Author
Yoon M
Park K
Lee H
Kim W
An T
Kim Y
Huang L
Hua C
Publication year
Publication venue
Journal of Korean medical science

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Snippet

The possible characteristics of spinal interaction between sildenafil (phosphodiesterase 5 inhibitor) and morphine on formalin-induced nociception in rats was examined. Then the role of the opioid receptor in the effect of sildenafil was further investigated. Catheters were …
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
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