Schirmbeck et al., 1994 - Google Patents
Immunization with soluble hepatitis B virus surface protein elicits murine H-2 class I-restricted CD8+ cytotoxic T lymphocyte responses in vivo.Schirmbeck et al., 1994
- Document ID
- 10028158462936619045
- Author
- Schirmbeck R
- Melber K
- Kuhröber A
- Janowicz Z
- Reimann J
- Publication year
- Publication venue
- Journal of immunology (Baltimore, Md.: 1950)
External Links
Snippet
Immunization with soluble proteins only rarely induces a specific response of CD8+ CTL. We describe experiments that demonstrate the efficient and specific in vivo priming of CTL in BALB/c mice immunized with soluble hepatitis B virus (HBV)-derived surface (S) protein. A …
- 230000004044 response 0 title abstract description 65
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Schirmbeck et al. | Immunization with soluble hepatitis B virus surface protein elicits murine H-2 class I-restricted CD8+ cytotoxic T lymphocyte responses in vivo. | |
| Schirmbeck et al. | Antibody and cytotoxic T-cell responses to soluble hepatitis B virus (HBV) S antigen in mice: implication for the pathogenesis of HBV-induced hepatitis | |
| Kuhöber et al. | DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice. | |
| Schirmbeck et al. | Nucleic acid vaccination primes hepatitis B virus surface antigen-specific cytotoxic T lymphocytes in nonresponder mice | |
| JP3738395B2 (en) | CTL epitope of HLA-restricted hepatitis B virus | |
| Doan et al. | Virus‐like particles as HIV‐1 vaccines | |
| Schirmbeck et al. | Processing of exogenous heat-aggregated (denatured) and particulate (native) hepatitis B surface antigen for class I-restricted epitope presentation. | |
| EP0804158B1 (en) | Compositions and methods for eliciting ctl immunity | |
| Kuhröber et al. | DNA vaccination with plasmids encoding the intracellular (HBcAg) or secreted (HBeAg) form of the core protein of hepatitis B virus primes T cell responses to two overlapping Kb-and Kd-restricted epitopes. | |
| Speidel et al. | Priming of cytotoxic T lymphocytes by five heat‐aggregated antigens in vivo: conditions, efficiency, and relation to antibody responses | |
| Schirmbeck et al. | Priming of class I-restricted cytotoxic T lymphocytes by vaccination with recombinant protein antigens | |
| Schirmbeck et al. | Similar as well as distinct MHC class I‐binding peptides are generated by exogenous and endogenous processing of hepatitis B virus surface antigen | |
| JP2002508748A (en) | Use of virus-like particles as adjuvants | |
| Schirmbeck et al. | Selective stimulation of murine cytotoxic T cell and antibody responses by particulate or monomeric hepatitis B virus surface (S) antigen | |
| Mihailova et al. | Recombinant virus-like particles as a carrier of B-and T-cell epitopes of hepatitis C virus (HCV) | |
| JPH06510050A (en) | Peptides that induce cytotoxic T lymphocyte responses to hepatitis B virus | |
| JP2024028762A (en) | Hepatitis b immunisation regimen and compositions | |
| EP1136077B1 (en) | Preparations containing virus-like particles as immunopotentiators administered through the mucosa | |
| US6458362B1 (en) | Recombinant VP2 parvoviral pseudo-particles encoding CTL or T-helper cell epitopes | |
| Yamashita et al. | Lack of immunodominance in the T cell response to herpes simplex virus glycoprotein D after administration of infectious virus. | |
| US8691234B2 (en) | Vaccine formulation potentiated by the combination of DNA and an antigen | |
| JP4917539B2 (en) | Vaccine composition against hepatitis C virus | |
| Davis | DNA-based immunization against hepatitis B: experience with animal models | |
| Davis | DNA-based vaccination against hepatitis B virus | |
| WO2023010176A1 (en) | Vaccine construct and uses thereof |