[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Larsson et al., 1980 - Google Patents

Inhibition of thrombin on surfaces coated with immobilized heparin and heparin-like polysaccharides: A crucial non-thrombogenic principle

Larsson et al., 1980

Document ID
10083835217352378695
Author
Larsson R
Olsson P
Lindahl U
Publication year
Publication venue
Thrombosis research

External Links

Snippet

Surfaces prepared from different sulphated polysaccharides and a polyethylene (PE) surface chemically modified with sulphate groups were examined in respect of their interaction with thrombin. Different fractions of heparin, heparan sulphate, dermatan …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/0005—Use of materials characterised by their function or physical properties
    • A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
    • A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Similar Documents

Publication Publication Date Title
Larsson et al. Inhibition of thrombin on surfaces coated with immobilized heparin and heparin-like polysaccharides: A crucial non-thrombogenic principle
Larm et al. A new non-thrombogenic surface prepared by selective covalent binding of heparin via a modified reducing terminal residue
AU762201B2 (en) Composition comprising heparin as a non-thrombogenic surface coating agent
Salzman et al. Effect of heparin and heparin fractions on platelet aggregation
EP0086186B1 (en) A process for covalent coupling for the production of conjugates, and products hereby obtained
US4800016A (en) Extracorporeal blood de-heparinization system
ES2242980T3 (en) DERMATAN DISULFATO, AN INHIBITOR OF THE THROMBIN GENERATION AND THE COMPLEMENT ACTIVATION.
JPH06506685A (en) Novel non-anticoagulant heparin derivative
JP2011017003A (en) Heparin-like compound, their production and use to prevent arterial thrombosis associated with vascular injury and intervention
JPH06502624A (en) Soluble hirudin complex
US5801063A (en) Device and process for the biospecific removal of heparin
Arnander et al. Thrombin uptake and inhibition on endothelium and surfaces with a stable heparin coating: a comparative in vitro study
Van der Kamp et al. Contact, coagulation and platelet interaction with heparin treated equipment during heart surgery
Arnander et al. Long-term stability in vivo of a thromboresistant heparinized surface
Zhang et al. Surface modification of polyvinyl chloride with sodium alginate/carboxymethyl chitosan and heparin for realizing the anticoagulation
AU4287100A (en) Hemocompatible surfaces and method for producing same
Araki et al. Heparin adheres to the damaged arterial wall and inhibits its thrombogenicity.
Castellot Jr et al. Endothelium, heparin, and the regulation of vascular smooth muscle cell growth
Arnander et al. Influence of blood flow and the effect of protamine on the thromboresistant properties of a covalently bonded heparin surface
Dryjski et al. Uptake and inhibition of thrombin by the vascular wall
Björck et al. Uptake and inactivation of thrombin by the fresh, glutardialdehyde or heparin treated human umbilical cord vein endothelium
Mason et al. Extracorporeal thrombogenesis and anticoagulation
Björck et al. In vitro evaluation of a biologic graft surface. Effect of treatment with conventional and low molecular weight (LMW) heparin
Kim et al. In vivo evaluation of DX-9065a, a synthetic factor Xa inhibitor, in experimental vein graft
Muramatsu et al. In vitro evaluation of the heparin‐coated Gyro C1E3 blood pump