Michael et al., 2002 - Google Patents
Defects in early insulin signaling in skeletal muscleMichael et al., 2002
- Document ID
- 10077103006056294051
- Author
- Michael M
- Kahn C
- Publication year
- Publication venue
- Muscle Metabolism
External Links
Snippet
Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MassachusettsType 2 diabetes mellitus is the most common endocrine disorder, affecting over 5% of the population in western countries (Warram et al., 1995) …
- 108009000068 Insulin Signaling 0 title abstract description 51
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New breeds of animals
- A01K67/027—New breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Lin et al. | Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1α null mice | |
Lin et al. | Current views on type 2 diabetes | |
Torisu et al. | The dual function of hepatic SOCS3 in insulin resistance in vivo | |
Warram et al. | Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents | |
Brüning et al. | Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles | |
Banks et al. | Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans | |
Ogawa et al. | Increased glucose metabolism and insulin sensitivity in transgenic skinny mice overexpressing leptin. | |
Mathews et al. | Improved insulin sensitivity and resistance to weight gain in mice null for the Ahsg gene | |
Huo et al. | Leptin-dependent control of glucose balance and locomotor activity by POMC neurons | |
Sesti et al. | Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms | |
Shimomura et al. | Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice | |
Smith et al. | Mice with a disruption of the imprinted Grb10 gene exhibit altered body composition, glucose homeostasis, and insulin signaling during postnatal life | |
Bouzakri et al. | Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes | |
Barbour et al. | Cellular mechanisms for insulin resistance in normal pregnancy and gestational diabetes. | |
Crunkhorn et al. | Links between thyroid hormone action, oxidative metabolism, and diabetes risk? | |
Kushner et al. | Cyclins D2 and D1 are essential for postnatal pancreatic β-cell growth | |
Andreelli et al. | Liver adenosine monophosphate-activated kinase-α2 catalytic subunit is a key target for the control of hepatic glucose production by adiponectin and leptin but not insulin | |
Meek et al. | BDNF action in the brain attenuates diabetic hyperglycemia via insulin-independent inhibition of hepatic glucose production | |
Ryder et al. | Skeletal muscle and insulin sensitivity: pathophysiological alterations | |
US7815895B2 (en) | Method for activating efferent sympathetic nerves innervating adipose tissues to improve obesity and symptoms associated therewith | |
Welsh et al. | Transgenic mice expressing Shb adaptor protein under the control of rat insulin promoter exhibit altered viability of pancreatic islet cells | |
Michael et al. | Defects in early insulin signaling in skeletal muscle | |
Paz et al. | Ser/Thr phosphorylation of insulin receptor signaling molecules and insulin resistence | |
Argyropoulos et al. | Genetics of the metabolic syndrome | |
Postic et al. | Mouse models of insulin resistance and type 2 diabetes |