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Gresack et al., 2014 - Google Patents

Inhibition of phosphodiesterase 10A has differential effects on dopamine D1 and D2 receptor modulation of sensorimotor gating

Gresack et al., 2014

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Document ID
1006914327488627641
Author
Gresack J
Seymour P
Schmidt C
Risbrough V
Publication year
Publication venue
Psychopharmacology

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Snippet

Rationale Inhibitors of phosphodiesterase 10A (PDE10A), an enzyme highly expressed in medium spiny neurons of the mammalian striatum, enhance activity in direct (dopamine D1 receptor-expressing) and indirect (D2 receptor-expressing striatal output) pathways. The …
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