Dam et al., 2005 - Google Patents
Galectins bind to the multivalent glycoprotein asialofetuin with enhanced affinities and a gradient of decreasing binding constantsDam et al., 2005
- Document ID
- 9432365183687167907
- Author
- Dam T
- Gabius H
- André S
- Kaltner H
- Lensch M
- Brewer C
- Publication year
- Publication venue
- Biochemistry
External Links
Snippet
Our previous isothermal titration microcalorimetry (ITC) studies of the binding of synthetic multivalent carbohydrates to the Man/Glc-specific lectins concanavalin A (ConA) and Dioclea grandiflora lectin (DGL) showed negative binding cooperativity that was due to the …
- 230000027455 binding 0 title abstract description 382
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Dam et al. | Galectins bind to the multivalent glycoprotein asialofetuin with enhanced affinities and a gradient of decreasing binding constants | |
| Cousin et al. | The role of galectin-1 in cancer progression, and synthetic multivalent systems for the study of galectin-1 | |
| Dings et al. | Galectins as molecular targets for therapeutic intervention | |
| Ludwig et al. | Design–functionality relationships for adhesion/growth-regulatory galectins | |
| Kamili et al. | Key regulators of galectin–glycan interactions | |
| Ahmed et al. | Galectin-3 as a potential target to prevent cancer metastasis | |
| Harada et al. | Oligosaccharyltransferase: a gatekeeper of health and tumor progression | |
| Soares et al. | Novel galectin-3 roles in neurogenesis, inflammation and neurological diseases | |
| André et al. | Persubstituted cyclodextrin-based glycoclusters as inhibitors of protein− carbohydrate recognition using purified plant and mammalian lectins and wild-type and lectin-gene-transfected tumor cells as targets | |
| Advedissian et al. | Galectin-7 in epithelial homeostasis and carcinomas | |
| Lauer et al. | Analysis of cholera toxin− ganglioside interactions by flow cytometry | |
| Dam et al. | Thermodynamics of multivalent carbohydrate− lectin cross-linking interactions: Importance of entropy in the bind and jump mechanism | |
| Murphy et al. | The third dimension of reading the sugar code by lectins: design of glycoclusters with cyclic scaffolds as tools with the aim to define correlations between spatial presentation and activity | |
| Tossetta et al. | Role of CD93 in Health and Disease | |
| Talaga et al. | Multitasking human lectin galectin-3 interacts with sulfated glycosaminoglycans and chondroitin sulfate proteoglycans | |
| Schwarz et al. | Thermodynamics of bovine spleen galectin-1 binding to disaccharides: correlation with structure and its effect on oligomerization at the denaturation temperature | |
| Gupta et al. | Thermodynamics of carbohydrate binding to galectin-1 from Chinese hamster ovary cells and two mutants. A comparison with four galactose-specific plant lectins | |
| Rodriguez et al. | Thermodynamic switch in binding of adhesion/growth regulatory human galectin-3 to tumor-associated TF antigen (CD176) and MUC1 glycopeptides | |
| Restuccia et al. | Evaluation of self-assembled glycopeptide nanofibers modified with N, N′-diacetyllactosamine for selective galectin-3 recognition and inhibition | |
| Kariya et al. | Roles of integrin α6β4 glycosylation in cancer | |
| Clarke et al. | Coacervation is promoted by molecular interactions between the PF2 segment of fibrillin-1 and the domain 4 region of tropoelastin | |
| Boutin et al. | Galectin-3 in kidney diseases: from an old protein to a new therapeutic target | |
| Zybura et al. | Distinctive properties and powerful neuromodulation of Nav1. 6 sodium channels regulates neuronal excitability | |
| Wautier et al. | Endothelial cell participation in inflammatory reaction | |
| Sewgobind et al. | Functions and inhibition of galectin-7, an emerging target in cellular pathophysiology |