[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Köchling, 1998 - Google Patents

Advancements in matrix-assisted laser desorption ionization mass spectrometry of peptides, proteins and polymers

Köchling, 1998

View PDF
Document ID
9425779992827216211
Author
Köchling H
Publication year

External Links

Snippet

Тhe matrix-assisted laser desorption/ionization (МАЦDI) technique for producing gasphase ions was shown to be compatible with a modified double-focussing magnetic sector mass spectrometer eduipped with an integrating focal plane array detector. Те ion source of the …
Continue reading at dspace.mit.edu (PDF) (other versions)

Classifications

    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
    • H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
    • H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/424—Three-dimensional ion traps, i.e. comprising end-cap and ring electrodes
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H01J49/405—Time-of-flight spectrometers characterised by the reflectron, e.g. curved field, electrode shapes
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/426—Methods for controlling ions
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0054—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by an electron beam, e.g. electron impact dissociation, electron capture dissociation
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H01J49/0045—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction
    • H01J49/0059—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn characterised by the fragmentation or other specific reaction by a photon beam, photo-dissociation
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/02—Details
    • H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
    • H01J49/0409—Sample holders or containers
    • H01J49/0413—Sample holders or containers for automated handling
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/02—Details
    • H01J49/025—Detectors specially adapted to particle spectrometers
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/02—Details
    • H01J49/10—Ion sources; Ion guns
    • H01J49/107—Arrangements for using several ion sources
    • H—ELECTRICITY
    • H01—BASIC ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometer or separator tubes
    • H01J49/0027—Methods for using particle spectrometers

Similar Documents

Publication Publication Date Title
EP0957508B1 (en) Analysis of biomolecules using time-of-flight mass spectrometry
US6002127A (en) Time-of-flight mass spectrometry analysis of biomolecules
Wang et al. Gas-phase cationization and protonation of neutrals generated by matrix-assisted laser desorption
US5654545A (en) Mass resolution in time-of-flight mass spectrometers with reflectors
Spengler et al. Ultraviolet laser desorption/ionization mass spectrometry of proteins above 100,000 daltons by pulsed ion extraction time-of-flight analysis
US7193206B2 (en) Ambient pressure matrix-assisted laser desorption ionization (MALDI) apparatus and method of analysis
JP2721029B2 (en) Method and apparatus for laser desorption of biomolecules
US7385187B2 (en) Multi-reflecting time-of-flight mass spectrometer and method of use
Salehpour et al. Laser‐induced desorption of proteins
KR20060026053A (en) Multi-reflecting time-of-flight mass spectrometer and a method of use
Hill et al. Matrix‐assisted laser desorption ionization with a magnetic mass spectrometer
Chevrier et al. A matrix‐assisted laser desorption time‐of‐flight mass spectrometer based on a 600ps, 1.2 mJ nitrogen laser
Westman et al. Sample exposure effects in matrix-assisted laser desorption—ionization mass spectrometry of large biomolecules
US20060138316A1 (en) Time-of-flight mass spectrometer
WO1999001889A1 (en) Novel mass spectrometer
US5744797A (en) Split-field interface
US8110795B2 (en) Laser system for MALDI mass spectrometry
Köchling Advancements in matrix-assisted laser desorption ionization mass spectrometry of peptides, proteins and polymers
JPH09320515A (en) Maldi-tof mass spectrograph
GB2468394A (en) Pulsed laser system for MALDI mass spectrometry
Baptista et al. Ion counting and ion intensity measurements in time‐of‐flight mass spectrometry. Application to matrix‐assisted laser desorption
US7301145B2 (en) Daughter ion spectra with time-of-flight mass spectrometers
Karas et al. Matrix-assisted laser desorption-ionization (MALDI) mass spectrometry: Principles and applications
EP1153414A1 (en) In-line reflecting time-of-flight mass spectrometer for molecular structural analysis using collision induced dissociation
Bush et al. Chapter 1: Introduction