Homan et al., 2019 - Google Patents
Flow-enhanced vascularization and maturation of kidney organoids in vitroHoman et al., 2019
View HTML- Document ID
- 9399661942240471800
- Author
- Homan K
- Gupta N
- Kroll K
- Kolesky D
- Skylar-Scott M
- Miyoshi T
- Mau D
- Valerius M
- Ferrante T
- Bonventre J
- Lewis J
- Morizane R
- Publication year
- Publication venue
- Nature methods
External Links
Snippet
Kidney organoids derived from human pluripotent stem cells have glomerular-and tubular- like compartments that are largely avascular and immature in static culture. Here we report an in vitro method for culturing kidney organoids under flow on millifluidic chips, which …
- 210000002220 Organoids 0 title abstract description 173
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
- C12N5/0602—Vertebrate cells
- C12N5/067—Hepatocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
- C12N5/0602—Vertebrate cells
- C12N5/0603—Embryonic cells ; Embryoid bodies
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
- G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/44—Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Homan et al. | Flow-enhanced vascularization and maturation of kidney organoids in vitro | |
| Zeng et al. | Generation of patterned kidney organoids that recapitulate the adult kidney collecting duct system from expandable ureteric bud progenitors | |
| Garreta et al. | Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells | |
| Munro et al. | Cycles of vascular plexus formation within the nephrogenic zone of the developing mouse kidney | |
| Homan et al. | Bioprinting of 3D convoluted renal proximal tubules on perfusable chips | |
| Campbell et al. | A multifunctional 3D co-culture system for studies of mammary tissue morphogenesis and stem cell biology | |
| Ciampi et al. | Engineering the vasculature of decellularized rat kidney scaffolds using human induced pluripotent stem cell-derived endothelial cells | |
| Lewis et al. | Complex bile duct network formation within liver decellularized extracellular matrix hydrogels | |
| Aceves et al. | 3D proximal tubule-on-chip model derived from kidney organoids with improved drug uptake | |
| Zhao et al. | Sox9 and Rbpj differentially regulate endothelial to mesenchymal transition and wound scarring in murine endovascular progenitors | |
| Yucer et al. | Directed differentiation of human induced pluripotent stem cells into fallopian tube epithelium | |
| Lukacs et al. | Isolation, cultivation and characterization of adult murine prostate stem cells | |
| Krause et al. | Exosomes as secondary inductive signals involved in kidney organogenesis | |
| Suzuki et al. | Directed differentiation of human induced pluripotent stem cells into mature stratified bladder urothelium | |
| Morizane et al. | Concise review: kidney generation with human pluripotent stem cells | |
| Bas-Cristóbal Menéndez et al. | Creating a kidney organoid-vasculature interaction model using a novel organ-on-chip system | |
| Plaza Reyes et al. | Identification of cell surface markers and establishment of monolayer differentiation to retinal pigment epithelial cells | |
| Qian et al. | Directed differentiation of human pluripotent stem cells to podocytes under defined conditions | |
| Yuri et al. | In vitro propagation and branching morphogenesis from single ureteric bud cells | |
| Kumar Gupta et al. | Asynchronous mixing of kidney progenitor cells potentiates nephrogenesis in organoids | |
| Mori et al. | Fabrication of perfusable vascular channels and capillaries in 3D liver-like tissue | |
| Beaton et al. | Wnt6 regulates epithelial cell differentiation and is dysregulated in renal fibrosis | |
| Kageyama et al. | In vitro hair follicle growth model for drug testing | |
| Dokras et al. | Regulation of human cytotrophoblast morphogenesis by hepatocyte growth factor/scatter factor | |
| Boutin et al. | 3D engineering of ocular tissues for disease modeling and drug testing |