Yang et al., 2012 - Google Patents
Expression of Escherichia coli virulence usher protein attenuates wild-type SalmonellaYang et al., 2012
View HTML- Document ID
- 9320986526978319178
- Author
- Yang X
- Suo Z
- Thornburg T
- Holderness K
- Cao L
- Lim T
- Walters N
- Kellerman L
- Loetterle L
- Avci R
- Pascual D
- Publication year
- Publication venue
- Virulence
External Links
Snippet
Generation of a live attenuated vaccine for bacterial pathogens often requires prior knowledge of the pathogen's virulence factors. We hypothesized an alternative approach of heterologous gene expression would make a wild-type (wt) pathogen more susceptible to …
- 206010039447 Salmonellosis 0 title abstract description 88
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0291—Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Micro-organisms or materials therefrom
- A61K35/74—Bacteria
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kong et al. | Effect of deletion of genes involved in lipopolysaccharide core and O-antigen synthesis on virulence and immunogenicity of Salmonella enterica serovar Typhimurium | |
| Dong et al. | Role of RpoS in virulence of pathogens | |
| Kong et al. | Phosphate groups of lipid A are essential for Salmonella enterica serovar Typhimurium virulence and affect innate and adaptive immunity | |
| Barat et al. | Immunity to intracellular Salmonella depends on surface-associated antigens | |
| Clapp et al. | Protective live oral brucellosis vaccines stimulate Th1 and Th17 cell responses | |
| Roland et al. | Salmonella as a vaccine delivery vehicle | |
| Leitner et al. | A combined vaccine approach against Vibrio cholerae and ETEC based on outer membrane vesicles | |
| Müller et al. | Role of RelA and SpoT in Burkholderia pseudomallei virulence and immunity | |
| Guo et al. | Immunologic properties and therapeutic efficacy of a multivalent epitope‐based vaccine against four Helicobacter pylori adhesins (urease, Lpp20, HpaA, and CagL) in Mongolian gerbils | |
| Łaniewski et al. | Evaluation of the immunogenicity of Campylobacter jejuni CjaA protein delivered by Salmonella enterica sv. Typhimurium strain with regulated delayed attenuation in chickens | |
| Liu et al. | Immunogenic characterization of outer membrane porins OmpC and OmpF of porcine extraintestinal pathogenic Escherichia coli | |
| Walker et al. | Vaccines against Shigella and enterotoxigenic Escherichia coli: a summary of the 2016 VASE Conference | |
| Tobias et al. | Surface expression of Helicobacter pylori HpaA adhesion antigen on Vibrio cholerae, enhanced by co-expressed enterotoxigenic Escherichia coli fimbrial antigens | |
| Medhekar et al. | Bordetella Bsp22 forms a filamentous type III secretion system tip complex and is immunoprotective in vitro and in vivo | |
| Kong et al. | Regulated delayed expression of rfaH in an attenuated Salmonella enterica serovar Typhimurium vaccine enhances immunogenicity of outer membrane proteins and a heterologous antigen | |
| Yang et al. | Expression of Escherichia coli virulence usher protein attenuates wild-type Salmonella | |
| Jawale et al. | Characterization of a Salmonella Typhimurium ghost carrying an adjuvant protein as a vaccine candidate for the protection of chickens against virulent challenge | |
| Hayes et al. | Bordetella pertussis iron regulated proteins as potential vaccine components | |
| Jagusztyn-Krynicka et al. | Update on Campylobacter jejuni vaccine development for preventing human campylobacteriosis | |
| Venkatesan et al. | Construction, characterization, and animal testing of WRSd1, a Shigella dysenteriae 1 vaccine | |
| Kudirkienė et al. | Chaperone-usher fimbriae in a diverse selection of Gallibacterium genomes | |
| Cai et al. | Yersinia enterocolitica ghost with msbB mutation provides protection and reduces proinflammatory cytokines in mice | |
| Sawa et al. | V‐antigen homologs in pathogenic gram‐negative bacteria | |
| Nagy et al. | “Gently rough”: the vaccine potential of a Salmonella enterica regulatory lipopolysaccharide mutant | |
| Zhao et al. | Two novel Salmonella bivalent vaccines confer dual protection against two Salmonella serovars in mice |