[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Krzewski et al., 2013 - Google Patents

LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity

Krzewski et al., 2013

View HTML
Document ID
9190888744005678219
Author
Krzewski K
Gil-Krzewska A
Nguyen V
Peruzzi G
Coligan J
Publication year
Publication venue
Blood, The Journal of the American Society of Hematology

External Links

Snippet

Secretory lysosomes of natural killer (NK) cells, containing perforin and granzymes, are indispensable for NK-cell cytotoxicity because their release results in the induction of target- cell apoptosis. Lysosome-associated membrane protein (LAMP) 1/CD107a is used as a …
Continue reading at www.sciencedirect.com (HTML) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids

Similar Documents

Publication Publication Date Title
Krzewski et al. LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity
Gestermann et al. Netting neutrophils activate autoreactive B cells in lupus
Li et al. Chronic mTOR activation induces a degradative smooth muscle cell phenotype
Noordenbos et al. Human mast cells capture, store, and release bioactive, exogenous IL-17A
Tang et al. Neutrophil extracellular trap formation is associated with autophagy-related signalling in ANCA-associated vasculitis
Tofiño-Vian et al. Microvesicles from human adipose tissue-derived mesenchymal stem cells as a new protective strategy in osteoarthritic chondrocytes
Sui et al. Tropomodulin3-null mice are embryonic lethal with anemia due to impaired erythroid terminal differentiation in the fetal liver
Goverse et al. Vitamin A controls the presence of RORγ+ innate lymphoid cells and lymphoid tissue in the small intestine
Montero-Melendez et al. Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis
Tong et al. Proteomic characterization of macro-, micro-and nano-extracellular vesicles derived from the same first trimester placenta: relevance for feto-maternal communication
Antiga et al. Regulatory T cells in the skin lesions and blood of patients with systemic sclerosis and morphoea
Marina-García et al. Clathrin-and dynamin-dependent endocytic pathway regulates muramyl dipeptide internalization and NOD2 activation
McLeod et al. The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression
Martin et al. Mouse neutrophils express the decoy type 2 interleukin-1 receptor (IL-1R2) constitutively and in acute inflammatory conditions
Tsai et al. Regulation of CD20 in rituximab-resistant cell lines and B-cell non-Hodgkin lymphoma
Nakashima et al. PAD4 regulates proliferation of multipotent haematopoietic cells by controlling c-myc expression
Kzhyshkowska et al. Alternatively activated macrophages regulate extracellular levels of the hormone placental lactogen via receptor-mediated uptake and transcytosis
Azouz et al. Rab5 is a novel regulator of mast cell secretory granules: impact on size, cargo, and exocytosis
Zen et al. Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state
Moeller et al. CD163-L1 is an endocytic macrophage protein strongly regulated by mediators in the inflammatory response
Immler et al. The voltage-gated potassium channel KV1. 3 regulates neutrophil recruitment during inflammation
Bist et al. Annexin-A1 regulates TLR-mediated IFN-β production through an interaction with TANK-binding kinase 1
Hüttl et al. Processing of CD74 by the intramembrane protease SPPL2a is critical for B cell receptor signaling in transitional B cells
Horton et al. Relaxin modulates proinflammatory cytokine secretion from human decidual macrophages
Carrión et al. VIP impairs acquisition of the macrophage proinflammatory polarization profile