[go: up one dir, main page]
More Web Proxy on the site http://driver.im/

Klein et al., 2001 - Google Patents

High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53

Klein et al., 2001

View HTML @Full View
Document ID
912370852156570740
Author
Klein C
Georges G
Kunkele K
Huber R
Engh R
Hansen S
Publication year
Publication venue
Journal of Biological Chemistry

External Links

Snippet

The p53 protein is the major tumor suppressor in mammals. The discovery of the p53 homologs p63 and p73 defined a family of p53 members with distinct roles in tumor suppression, differentiation, and development. Here, we describe the biochemical …
Continue reading at www.jbc.org (HTML) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids

Similar Documents

Publication Publication Date Title
Klein et al. High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53
Bova et al. Subunit exchange of small heat shock proteins: analysis of oligomer formation of αA-crystallin and Hsp27 by fluorescence resonance energy transfer and site-directed truncations
Musco et al. Towards a structural understanding of Friedreich’s ataxia: the solution structure of frataxin
Linnemann et al. Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily
Richter et al. Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H
Waters et al. In vitro expression analysis of mutations in phenylalanine hydroxylase: linking genotype to phenotype and structure to function
Richards et al. Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB
Matsushita et al. Substrate Recognition by the Collagen-binding Domain ofClostridium histolyticum Class I Collagenase
Montgomery et al. Mutations in the substrate binding domain of the Escherichia coli 70 kDa molecular chaperone, DnaK, which alter substrate affinity or interdomain coupling
Rafie-Kolpin et al. Two heme-binding domains of heme-regulated eukaryotic initiation factor-2α kinase: N terminus and kinase insertion
Szczesna et al. Familial hypertrophic cardiomyopathy mutations in the regulatory light chains of myosin affect their structure, Ca2+ binding, and phosphorylation
Thoden et al. Molecular structure of galactokinase
White et al. Characterization of recombinant HPV6 and 11 E1 helicases: effect of ATP on the interaction of E1 with E2 and mapping of a minimal helicase domain
Harris et al. Both the structure and DNA binding function of the barrier-to-autointegration factor contribute to reconstitution of HIV type 1 integration in vitro
León et al. A stable α-helical domain at the N terminus of the RIα subunits of cAMP-dependent protein kinase is a novel dimerization/docking motif
Gatto et al. The M4M5 cytoplasmic loop of the Na, K-ATPase, overexpressed in Escherichia coli, binds nucleoside triphosphates with the same selectivity as the intact native protein
Brandt et al. Stability of p53 homologs
Muzzin et al. Disruption of Escherichia coli hepA, an RNA polymerase-associated protein, causes UV sensitivity
Ward et al. Structural consequences of cardiac troponin I phosphorylation
Choi et al. Biophysical characterization of the interaction domains and mapping of the contact residues in the XPF-ERCC1 complex
Kumagai et al. Correct partner makes the difference: Septin G-interface plays a critical role in amyloid formation
Chen et al. Mapping the Gα13 binding interface of the rgRGS domain of p115RhoGEF
Natochin et al. Identification of effector residues on photoreceptor G protein, transducin
Oliveira et al. Mapping the domain of troponin T responsible for the activation of actomyosin ATPase activity: identification of residues involved in binding to actin
Remmert et al. CARMIL is a bona fide capping protein interactant